Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms

C.C.H. Wielders, V.H. Hackert, B. Schimmer, H.M. Hodemaekers, A. de Klerk, C.J.P.A. Hoebe, P.M. Schneeberger, Y.H.T.P. van Duynhoven, R. Janssen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.

Original languageEnglish
Pages (from-to)943-950
Number of pages8
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume34
Issue number5
DOIs
Publication statusPublished - May 2015

Keywords

  • RESPIRATORY SYNCYTIAL VIRUS
  • INTERFERON-GAMMA GENE
  • D-RECEPTOR GENE
  • COXIELLA-BURNETII
  • INFECTIOUS-DISEASES
  • FATIGUE SYNDROME
  • ASSOCIATION
  • TUBERCULOSIS
  • SUSCEPTIBILITY
  • NETHERLANDS

Cite this

Wielders, C. C. H., Hackert, V. H., Schimmer, B., Hodemaekers, H. M., de Klerk, A., Hoebe, C. J. P. A., Schneeberger, P. M., van Duynhoven, Y. H. T. P., & Janssen, R. (2015). Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms. European Journal of Clinical Microbiology & Infectious Diseases, 34(5), 943-950. https://doi.org/10.1007/s10096-014-2310-9