Noninvasive pulmonary transit time: A new parameter for general cardiac performance

Anouk G. W. de Lepper; Ingeborg H. F. Herold; Salvatore Saporito; R. Arthur Bouwman; Massimo Mischi; Hendrikus H. M. Korsten; Koen D. Reesink; Patrick Houthuizen

doi:10.1111/echo.13590

Noninvasive pulmonary transit time: A new parameter for general cardiac performance

Anouk G. W. de Lepper^*, Ingeborg H. F. Herold, Salvatore Saporito, R. Arthur Bouwman, Massimo Mischi, Hendrikus H. M. Korsten, Koen D. Reesink, Patrick Houthuizen

^*Corresponding author for this work

Biomedische Technologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).

Methods: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)= 120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson's or Spearman's coefficients and stratified for rhythm and NYHA class.

Results: The study population consisted of 94 patients (67 men) with a mean age of 70 +/- 8.9 years. (n)PTT was significantly correlated with left ventricular parameters (r(s)=-(.)487. P

Conclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.

Original language	English
Pages (from-to)	1138-1145
Number of pages	8
Journal	Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
Volume	34
Issue number	8
DOIs	https://doi.org/10.1111/echo.13590
Publication status	Published - Aug 2017

Keywords

contrast echocardiography
diastolic dysfunction
heart failure
left ventricular function
right ventricular function
systolic function
pulmonary transit time
CONGESTIVE-HEART-FAILURE
BLOOD-VOLUME
CONTRAST ECHOCARDIOGRAPHY
QUANTIFICATION
ULTRASOUND
FEASIBILITY
CHAMBER
OUTPUT

Access to Document

10.1111/echo.13590

Cite this

@article{98470a95d53a4c079d581690d4dff17f,

title = "Noninvasive pulmonary transit time: A new parameter for general cardiac performance",

abstract = "Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).Methods: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)= 120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson's or Spearman's coefficients and stratified for rhythm and NYHA class.Results: The study population consisted of 94 patients (67 men) with a mean age of 70 +/- 8.9 years. (n)PTT was significantly correlated with left ventricular parameters (r(s)=-(.)487. PConclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.",

keywords = "contrast echocardiography, diastolic dysfunction, heart failure, left ventricular function, right ventricular function, systolic function, pulmonary transit time, CONGESTIVE-HEART-FAILURE, BLOOD-VOLUME, CONTRAST ECHOCARDIOGRAPHY, QUANTIFICATION, ULTRASOUND, FEASIBILITY, CHAMBER, OUTPUT",

author = "{de Lepper}, {Anouk G. W.} and Herold, {Ingeborg H. F.} and Salvatore Saporito and Bouwman, {R. Arthur} and Massimo Mischi and Korsten, {Hendrikus H. M.} and Reesink, {Koen D.} and Patrick Houthuizen",

year = "2017",

month = aug,

doi = "10.1111/echo.13590",

language = "English",

volume = "34",

pages = "1138--1145",

journal = "Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques",

issn = "0742-2822",

publisher = "Wiley",

number = "8",

}

TY - JOUR

T1 - Noninvasive pulmonary transit time

T2 - A new parameter for general cardiac performance

AU - de Lepper, Anouk G. W.

AU - Herold, Ingeborg H. F.

AU - Saporito, Salvatore

AU - Bouwman, R. Arthur

AU - Mischi, Massimo

AU - Korsten, Hendrikus H. M.

AU - Reesink, Koen D.

AU - Houthuizen, Patrick

PY - 2017/8

Y1 - 2017/8

N2 - Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).Methods: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)= 120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson's or Spearman's coefficients and stratified for rhythm and NYHA class.Results: The study population consisted of 94 patients (67 men) with a mean age of 70 +/- 8.9 years. (n)PTT was significantly correlated with left ventricular parameters (r(s)=-(.)487. PConclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.

AB - Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).Methods: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)= 120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson's or Spearman's coefficients and stratified for rhythm and NYHA class.Results: The study population consisted of 94 patients (67 men) with a mean age of 70 +/- 8.9 years. (n)PTT was significantly correlated with left ventricular parameters (r(s)=-(.)487. PConclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.

KW - contrast echocardiography

KW - diastolic dysfunction

KW - heart failure

KW - left ventricular function

KW - right ventricular function

KW - systolic function

KW - pulmonary transit time

KW - CONGESTIVE-HEART-FAILURE

KW - BLOOD-VOLUME

KW - CONTRAST ECHOCARDIOGRAPHY

KW - QUANTIFICATION

KW - ULTRASOUND

KW - FEASIBILITY

KW - CHAMBER

KW - OUTPUT

U2 - 10.1111/echo.13590

DO - 10.1111/echo.13590

M3 - Article

C2 - 28600804

SN - 0742-2822

VL - 34

SP - 1138

EP - 1145

JO - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques

JF - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques

IS - 8

ER -