Noninvasive pulmonary transit time: A new parameter for general cardiac performance

Anouk G. W. de Lepper*, Ingeborg H. F. Herold, Salvatore Saporito, R. Arthur Bouwman, Massimo Mischi, Hendrikus H. M. Korsten, Koen D. Reesink, Patrick Houthuizen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).

Methods: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)= 120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson's or Spearman's coefficients and stratified for rhythm and NYHA class.

Results: The study population consisted of 94 patients (67 men) with a mean age of 70 +/- 8.9 years. (n)PTT was significantly correlated with left ventricular parameters (r(s)=-(.)487. P

Conclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.

Original languageEnglish
Pages (from-to)1138-1145
Number of pages8
JournalEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
Issue number8
Publication statusPublished - Aug 2017


  • contrast echocardiography
  • diastolic dysfunction
  • heart failure
  • left ventricular function
  • right ventricular function
  • systolic function
  • pulmonary transit time

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