Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jan Fiedler; Andrew H. Baker; Stefanie Dimmeler; Stephane Heymans; Manuel Mayr; Thomas Thum

doi:10.1093/cvr/cvy121

Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jan Fiedler, Andrew H. Baker, Stefanie Dimmeler, Stephane Heymans, Manuel Mayr, Thomas Thum^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics and biomarkers. We hereby review recent insights relating to non-coding RNAs including microRNAs (e.g. miR-126, miR-146a), long non-coding RNAs (e.g. MIR503HG, GATA6-AS, SMILR), and circular RNAs (e.g. cZNF292) and their role in vascular diseases. This includes identification and therapeutic use of hypoxia-regulated non-coding RNAs and endogenous non-coding RNAs that regulate intrinsic smooth muscle cell signalling, age-related non-coding RNAs, and non-coding RNAs involved in the regulation of mitochondrial biology and metabolic control. Finally, we discuss non-coding RNA species with biomarker potential.

Original language	English
Pages (from-to)	1281-1286
Number of pages	6
Journal	Cardiovascular Research
Volume	114
Issue number	10
DOIs	https://doi.org/10.1093/cvr/cvy121
Publication status	Published - 1 Aug 2018

Keywords

Non-coding RNA
Vascular disease
Biomarker
CIRCULATING MICRORNAS
CARDIAC-HYPERTROPHY
CELL-PROLIFERATION
DYSFUNCTION
INFARCTION
ATHEROSCLEROSIS
OVEREXPRESSION
IDENTIFICATION
INHIBITION
ACTIVATION

Access to Document

10.1093/cvr/cvy121

Cite this

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title = "Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology",

abstract = "Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics and biomarkers. We hereby review recent insights relating to non-coding RNAs including microRNAs (e.g. miR-126, miR-146a), long non-coding RNAs (e.g. MIR503HG, GATA6-AS, SMILR), and circular RNAs (e.g. cZNF292) and their role in vascular diseases. This includes identification and therapeutic use of hypoxia-regulated non-coding RNAs and endogenous non-coding RNAs that regulate intrinsic smooth muscle cell signalling, age-related non-coding RNAs, and non-coding RNAs involved in the regulation of mitochondrial biology and metabolic control. Finally, we discuss non-coding RNA species with biomarker potential.",

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author = "Jan Fiedler and Baker, {Andrew H.} and Stefanie Dimmeler and Stephane Heymans and Manuel Mayr and Thomas Thum",

year = "2018",

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journal = "Cardiovascular Research",

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Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. / Fiedler, Jan; Baker, Andrew H.; Dimmeler, Stefanie et al.
In: Cardiovascular Research, Vol. 114, No. 10, 01.08.2018, p. 1281-1286.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Mayr, Manuel

AU - Thum, Thomas

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KW - DYSFUNCTION

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KW - ATHEROSCLEROSIS

KW - OVEREXPRESSION

KW - IDENTIFICATION

KW - INHIBITION

KW - ACTIVATION

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