Abstract
Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics and biomarkers. We hereby review recent insights relating to non-coding RNAs including microRNAs (e.g. miR-126, miR-146a), long non-coding RNAs (e.g. MIR503HG, GATA6-AS, SMILR), and circular RNAs (e.g. cZNF292) and their role in vascular diseases. This includes identification and therapeutic use of hypoxia-regulated non-coding RNAs and endogenous non-coding RNAs that regulate intrinsic smooth muscle cell signalling, age-related non-coding RNAs, and non-coding RNAs involved in the regulation of mitochondrial biology and metabolic control. Finally, we discuss non-coding RNA species with biomarker potential.
Original language | English |
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Pages (from-to) | 1281-1286 |
Number of pages | 6 |
Journal | Cardiovascular Research |
Volume | 114 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Aug 2018 |
Keywords
- Non-coding RNA
- Vascular disease
- Biomarker
- CIRCULATING MICRORNAS
- CARDIAC-HYPERTROPHY
- CELL-PROLIFERATION
- DYSFUNCTION
- INFARCTION
- ATHEROSCLEROSIS
- OVEREXPRESSION
- IDENTIFICATION
- INHIBITION
- ACTIVATION