Abstract
Background: In 2002, the European Society of Cardiology conducted the Euro Heart Survey (EHS), while in 2014concluded 1-year follow-up of the EURObservational Research Programme AF (EORP-AF) Pilot Registry. Methods: We analysed differences in clinical profiles, therapeutic approaches and outcomes between these two cohorts after propensity score matching (PSM). Results: After PSM, 5206 patients were analysed. In EORP-AF there were more elderly patients than EHS (p<.001). EORP-AF patients were more burdened with cardiovascular (CV) and non-CV comorbidities, with a higher proportion of patients with high thromboembolic risk. EORP-AF patients used more oral-anticoagulant (OAC) (p<.001). At 1-year follow-up EORP-AF patients had lower risk for thromboembolic and CV events, readmission for AF and other CV reasons (all p<.001), showing conversely a higher risk for CV death (p=.015). Kaplan-Meier curves showed that EORP-AF patients had higher risk for CV death (p<.0001) and all-cause death (p=.0019). Cox regression confirmed that EORP-AF patients were at higher risk for CV death (p=.021). Conclusions: We found significant changes in AF epidemiology over a decade in Europe, with older patients, more burdened with comorbidities. A greater use of OAC was found. Despite a reduction in risk for thromboembolic events, a high risk of CV-related death was still evident.
Original language | English |
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Pages (from-to) | 28-34 |
Number of pages | 7 |
Journal | European journal of internal medicine |
Volume | 55 |
DOIs | |
Publication status | Published - 1 Sept 2018 |
Keywords
- Atrial fibrillation
- Epidemiology
- Europe
- Thromboembolic risk
- Mortality
- GENERAL REGISTRY
- HEART SURVEY
- FOLLOW-UP
- MEMBER COUNTRIES
- MANAGEMENT
- DISEASE
- STROKE
- THROMBOEMBOLISM
- PROGNOSIS
- EVENTS