Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: A comparison between EORP-AF pilot and EHS-AF registries

Marco Proietti, Cecile Laroche, Robby Nieuwlaat, Harry J. G. M. Crijns, Aldo P. Maggioni, Deirdre A. Lane, Giuseppe Boriani, Gregory Y. H. Lip*, EORP-AF Gen Pilot Registry; Euro Heart Survey AF Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Web of Science)

Abstract

Background: In 2002, the European Society of Cardiology conducted the Euro Heart Survey (EHS), while in 2014concluded 1-year follow-up of the EURObservational Research Programme AF (EORP-AF) Pilot Registry. Methods: We analysed differences in clinical profiles, therapeutic approaches and outcomes between these two cohorts after propensity score matching (PSM). Results: After PSM, 5206 patients were analysed. In EORP-AF there were more elderly patients than EHS (p<.001). EORP-AF patients were more burdened with cardiovascular (CV) and non-CV comorbidities, with a higher proportion of patients with high thromboembolic risk. EORP-AF patients used more oral-anticoagulant (OAC) (p<.001). At 1-year follow-up EORP-AF patients had lower risk for thromboembolic and CV events, readmission for AF and other CV reasons (all p<.001), showing conversely a higher risk for CV death (p=.015). Kaplan-Meier curves showed that EORP-AF patients had higher risk for CV death (p<.0001) and all-cause death (p=.0019). Cox regression confirmed that EORP-AF patients were at higher risk for CV death (p=.021). Conclusions: We found significant changes in AF epidemiology over a decade in Europe, with older patients, more burdened with comorbidities. A greater use of OAC was found. Despite a reduction in risk for thromboembolic events, a high risk of CV-related death was still evident.
Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalEuropean journal of internal medicine
Volume55
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Atrial fibrillation
  • Epidemiology
  • Europe
  • Thromboembolic risk
  • Mortality
  • GENERAL REGISTRY
  • HEART SURVEY
  • FOLLOW-UP
  • MEMBER COUNTRIES
  • MANAGEMENT
  • DISEASE
  • STROKE
  • THROMBOEMBOLISM
  • PROGNOSIS
  • EVENTS

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