Abstract
Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.
Original language | English |
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Pages (from-to) | 1003-1012 |
Number of pages | 10 |
Journal | Pharmacogenomics |
Volume | 18 |
Issue number | 10 |
DOIs | |
Publication status | Published - Jul 2017 |
Keywords
- Caribbean
- CYP2C19
- CYP2D6
- ethnicity
- prevalence
- psychiatry
- DEBRISOQUINE 4-HYDROXYLASE CYP2D6
- GENETIC POLYMORPHISMS
- TARDIVE-DYSKINESIA
- HEALTHY-VOLUNTEERS
- COST-EFFECTIVENESS
- ALLELE FREQUENCY
- SCHIZOPHRENIA
- CYTOCHROME-P450
- PHARMACOGENETICS
- IMPLEMENTATION