CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Anne B. Koopmans*, David J. Vinkers, Petra J. A. Gelan, Hans W. Hoek, Peter N. van Harten

*Corresponding author for this work

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Abstract

Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

Original languageEnglish
Pages (from-to)1003-1012
Number of pages10
JournalPharmacogenomics
Volume18
Issue number10
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Caribbean
  • CYP2C19
  • CYP2D6
  • ethnicity
  • prevalence
  • psychiatry
  • DEBRISOQUINE 4-HYDROXYLASE CYP2D6
  • GENETIC POLYMORPHISMS
  • TARDIVE-DYSKINESIA
  • HEALTHY-VOLUNTEERS
  • COST-EFFECTIVENESS
  • ALLELE FREQUENCY
  • SCHIZOPHRENIA
  • CYTOCHROME-P450
  • PHARMACOGENETICS
  • IMPLEMENTATION

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