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Comparative analysis of the macroscale structural connectivity in the macaque and human brain

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Abstract

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

    Research areas

  • FUNCTIONAL-ORGANIZATION, CORTICAL PARCELLATIONS, PREFRONTAL CORTEX, PARIETAL CORTEX, FRONTAL-CORTEX, DIFFUSION MRI, MONKEY, NETWORKS, PATHWAYS, RECONSTRUCTION
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Details

Original languageEnglish
Article numbere1003529
Number of pages15
JournalPLoS Computational Biology
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2014