The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.
- CORTICAL PARCELLATIONS
- PREFRONTAL CORTEX
- PARIETAL CORTEX
- DIFFUSION MRI
Goulas, A., Bastiani, M., Bezgin, G., Uylings, H. B. M., Roebroeck, A., & Stiers, P. (2014). Comparative analysis of the macroscale structural connectivity in the macaque and human brain. PLoS Computational Biology, 10(3), [e1003529]. https://doi.org/10.1371/journal.pcbi.1003529