Annexin A1 and annexin A5 in cardiovascular disease

D.H.M. Kusters

doi:10.26481/dis.20150206dk

Annexin A1 and annexin A5 in cardiovascular disease

D.H.M. Kusters

Biochemie

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

This study involves two members of the annexin family of proteins and their relationship to cardiovascular disease. The main findings are the inhibiting effect of annexin A5 on clearing away dead cells and, therefore, the enhancing effect on ‘arteriosclerosis’. Annexin A1 has an anti-inflammatory effect and was successful in the treatment of ‘arteriosclerosis’ as well as the reduction of damage following myocardial infarction. These findings may lead to the development of new drugs.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Reutelingsperger, Christiaan, Supervisor Schurgers, Leon, Co-Supervisor
Award date	6 Feb 2015
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789462950801
DOIs	https://doi.org/10.26481/dis.20150206dk
Publication status	Published - 2015

Keywords

cardiovascular disease
proteins
arteriosclerosis

Access to Document

10.26481/dis.20150206dk

Full TextFinal published version, 7.35 MB
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Cite this

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AB - This study involves two members of the annexin family of proteins and their relationship to cardiovascular disease. The main findings are the inhibiting effect of annexin A5 on clearing away dead cells and, therefore, the enhancing effect on ‘arteriosclerosis’. Annexin A1 has an anti-inflammatory effect and was successful in the treatment of ‘arteriosclerosis’ as well as the reduction of damage following myocardial infarction. These findings may lead to the development of new drugs.

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KW - proteins

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