Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma

Z.C. Qiu; F.F. Lin; Z. Wu; T.H. Wu; M.L. Wang; J. Hu; D.H. Xie; S. Lyu; J. Ma; Y.L. Tao; Y. Su

doi:10.1002/hed.27334

Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma

Z.C. Qiu, F.F. Lin, Z. Wu, T.H. Wu, M.L. Wang, J. Hu, D.H. Xie, S. Lyu, J. Ma, Y.L. Tao^*, Y. Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BackgroundMost nasopharyngeal carcinoma (NPC) protocols define primary gross tumor volume (GTVnx) plus a range from 2 to 5 mm as the high-dose clinical target volume (hd-CTV). However, in China, hd-CTV is defined as GTVnx plus 0 mm. MethodsA total of 40 patients with newly diagnosed nonmetastatic NPC (T1-T4 ten cases each) treated with IMRT were consecutively enrolled. Real and virtual treatment plans were designed according to the definitions of hd-CTV recommended by China and Radiation Therapy Oncology Group (RTOG), respectively. ResultsThe hd-CTV in China was significantly smaller than that of RTOG. Exposure doses to 5 mm subclinical involvement and OARs as well as NTCP in the China treatment plan were significantly lower than those of RTOG. ConclusionIt could be recommended to divide the hd-CTV into GTV and subclinical target volume and to prescribe different doses for the GTV and subclinical involvement in the IMRT plan of NPC.

Original language	English
Pages (from-to)	1206-1214
Number of pages	9
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	45
Issue number	5
Early online date	1 Mar 2023
DOIs	https://doi.org/10.1002/hed.27334
Publication status	Published - May 2023

Keywords

CTV
IMRT
nasopharyngeal carcinoma
NTCP
SQUAMOUS-CELL CARCINOMA
RADIATION-THERAPY
RESPONSE RELATIONSHIP
REGIONAL FAILURE
NECK-CANCER
ORAL-CAVITY
DELINEATION
PATTERNS
OUTCOMES

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10.1002/hed.27334

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Qiu, Z. C., Lin, F. F., Wu, Z., Wu, T. H., Wang, M. L., Hu, J., Xie, D. H., Lyu, S., Ma, J., Tao, Y. L., & Su, Y. (2023). Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 45(5), 1206-1214. https://doi.org/10.1002/hed.27334

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title = "Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma",

abstract = "BackgroundMost nasopharyngeal carcinoma (NPC) protocols define primary gross tumor volume (GTVnx) plus a range from 2 to 5 mm as the high-dose clinical target volume (hd-CTV). However, in China, hd-CTV is defined as GTVnx plus 0 mm. MethodsA total of 40 patients with newly diagnosed nonmetastatic NPC (T1-T4 ten cases each) treated with IMRT were consecutively enrolled. Real and virtual treatment plans were designed according to the definitions of hd-CTV recommended by China and Radiation Therapy Oncology Group (RTOG), respectively. ResultsThe hd-CTV in China was significantly smaller than that of RTOG. Exposure doses to 5 mm subclinical involvement and OARs as well as NTCP in the China treatment plan were significantly lower than those of RTOG. ConclusionIt could be recommended to divide the hd-CTV into GTV and subclinical target volume and to prescribe different doses for the GTV and subclinical involvement in the IMRT plan of NPC.",

keywords = "CTV, IMRT, nasopharyngeal carcinoma, NTCP, SQUAMOUS-CELL CARCINOMA, RADIATION-THERAPY, RESPONSE RELATIONSHIP, REGIONAL FAILURE, NECK-CANCER, ORAL-CAVITY, DELINEATION, PATTERNS, OUTCOMES",

author = "Z.C. Qiu and F.F. Lin and Z. Wu and T.H. Wu and M.L. Wang and J. Hu and D.H. Xie and S. Lyu and J. Ma and Y.L. Tao and Y. Su",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = may,

doi = "10.1002/hed.27334",

language = "English",

volume = "45",

pages = "1206--1214",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "5",

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Qiu, ZC, Lin, FF, Wu, Z, Wu, TH, Wang, ML, Hu, J, Xie, DH, Lyu, S, Ma, J, Tao, YL & Su, Y 2023, 'Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma', Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 45, no. 5, pp. 1206-1214. https://doi.org/10.1002/hed.27334

Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma. / Qiu, Z.C.; Lin, F.F.; Wu, Z. et al.
In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, Vol. 45, No. 5, 05.2023, p. 1206-1214.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma

AU - Qiu, Z.C.

AU - Lin, F.F.

AU - Wu, Z.

AU - Wu, T.H.

AU - Wang, M.L.

AU - Hu, J.

AU - Xie, D.H.

AU - Lyu, S.

AU - Ma, J.

AU - Tao, Y.L.

AU - Su, Y.

PY - 2023/5

Y1 - 2023/5

N2 - BackgroundMost nasopharyngeal carcinoma (NPC) protocols define primary gross tumor volume (GTVnx) plus a range from 2 to 5 mm as the high-dose clinical target volume (hd-CTV). However, in China, hd-CTV is defined as GTVnx plus 0 mm. MethodsA total of 40 patients with newly diagnosed nonmetastatic NPC (T1-T4 ten cases each) treated with IMRT were consecutively enrolled. Real and virtual treatment plans were designed according to the definitions of hd-CTV recommended by China and Radiation Therapy Oncology Group (RTOG), respectively. ResultsThe hd-CTV in China was significantly smaller than that of RTOG. Exposure doses to 5 mm subclinical involvement and OARs as well as NTCP in the China treatment plan were significantly lower than those of RTOG. ConclusionIt could be recommended to divide the hd-CTV into GTV and subclinical target volume and to prescribe different doses for the GTV and subclinical involvement in the IMRT plan of NPC.

AB - BackgroundMost nasopharyngeal carcinoma (NPC) protocols define primary gross tumor volume (GTVnx) plus a range from 2 to 5 mm as the high-dose clinical target volume (hd-CTV). However, in China, hd-CTV is defined as GTVnx plus 0 mm. MethodsA total of 40 patients with newly diagnosed nonmetastatic NPC (T1-T4 ten cases each) treated with IMRT were consecutively enrolled. Real and virtual treatment plans were designed according to the definitions of hd-CTV recommended by China and Radiation Therapy Oncology Group (RTOG), respectively. ResultsThe hd-CTV in China was significantly smaller than that of RTOG. Exposure doses to 5 mm subclinical involvement and OARs as well as NTCP in the China treatment plan were significantly lower than those of RTOG. ConclusionIt could be recommended to divide the hd-CTV into GTV and subclinical target volume and to prescribe different doses for the GTV and subclinical involvement in the IMRT plan of NPC.

KW - CTV

KW - IMRT

KW - nasopharyngeal carcinoma

KW - NTCP

KW - SQUAMOUS-CELL CARCINOMA

KW - RADIATION-THERAPY

KW - RESPONSE RELATIONSHIP

KW - REGIONAL FAILURE

KW - NECK-CANCER

KW - ORAL-CAVITY

KW - DELINEATION

KW - PATTERNS

KW - OUTCOMES

U2 - 10.1002/hed.27334

DO - 10.1002/hed.27334

M3 - Article

C2 - 36856344

SN - 1043-3074

VL - 45

SP - 1206

EP - 1214

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IS - 5

ER -

Qiu ZC, Lin FF, Wu Z, Wu TH, Wang ML, Hu J et al. Why subclinical involvement is prescribed the same high dose as gross tumor volume: A study on high-dose clinical target volume in intensity-modulated radiotherapy plan of nasopharyngeal carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2023 May;45(5):1206-1214. Epub 2023 Mar 1. doi: 10.1002/hed.27334