Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Ruben Coronel, Mark Potse, Michel Haïssaguerre, Nicolas Derval, Mathilde R Rivaud, Veronique M F Meijborg, Matthijs Cluitmans, Mélèze Hocini, Bastiaan J Boukens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)


Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

Original languageEnglish
Article number648396
Number of pages6
JournalFrontiers in physiology
Publication statusPublished - 23 Mar 2021
Externally publishedYes


  • Purkinje
  • ablation
  • arrhythmias
  • early repolarization syndrome
  • electrophysiology
  • idiopathic ventricular fibrillation

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