Whither systems medicine?

Rolf Apweiler; Tim Beissbarth; Michael R. Berthold; Nils Bluethgen; Yvonne Burmeister; Olaf Dammann; Andreas Deutsch; Friedrich Feuerhake; Andre Franke; Jan Hasenauer; Steve Hoffmann; Thomas Hoefer; Peter L. M. Jansen; Lars Kaderali; Ursula Klingmueller; Ina Koch; Oliver Kohlbacher; Lars Kuepfer; Frank Lammert; Dieter Maier; Nico Pfeifer; Nicole Radde; Markus Rehm; Ingo Roeder; Julio Saez-Rodriguez; Ulrich Sax; Bernd Schmeck; Andreas Schuppert; Bernd Seilheimer; Fabian J. Theis; Julio Vera; Olaf Wolkenhauer

doi:10.1038/emm.2017.290

Whither systems medicine?

Rolf Apweiler, Tim Beissbarth, Michael R. Berthold, Nils Bluethgen, Yvonne Burmeister, Olaf Dammann, Andreas Deutsch, Friedrich Feuerhake, Andre Franke, Jan Hasenauer, Steve Hoffmann, Thomas Hoefer, Peter L. M. Jansen, Lars Kaderali, Ursula Klingmueller, Ina Koch, Oliver Kohlbacher, Lars Kuepfer, Frank Lammert, Dieter MaierNico Pfeifer, Nicole Radde, Markus Rehm, Ingo Roeder, Julio Saez-Rodriguez, Ulrich Sax, Bernd Schmeck, Andreas Schuppert, Bernd Seilheimer, Fabian J. Theis, Julio Vera, Olaf Wolkenhauer^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.

Original language	English
Article number	453
Number of pages	6
Journal	Experimental and Molecular Medicine
Volume	50
Issue number	3
DOIs	https://doi.org/10.1038/emm.2017.290
Publication status	Published - 2 Mar 2018

Keywords

SINGLE-CELL ANALYSIS
COLORECTAL-CANCER
BIG DATA
PHARMACOLOGY
BIOLOGY
GENERATION
MECHANISMS
MODELS
TOOLS
Humans
Translational Medical Research
Decision Support Systems, Clinical
Systems Analysis
Biomedical Research

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10.1038/emm.2017.290Licence: CC BY

Cite this

Apweiler, R., Beissbarth, T., Berthold, M. R., Bluethgen, N., Burmeister, Y., Dammann, O., Deutsch, A., Feuerhake, F., Franke, A., Hasenauer, J., Hoffmann, S., Hoefer, T., Jansen, P. L. M., Kaderali, L., Klingmueller, U., Koch, I., Kohlbacher, O., Kuepfer, L., Lammert, F., ... Wolkenhauer, O. (2018). Whither systems medicine? Experimental and Molecular Medicine, 50(3), Article 453. https://doi.org/10.1038/emm.2017.290

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title = "Whither systems medicine?",

abstract = "New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.",

keywords = "SINGLE-CELL ANALYSIS, COLORECTAL-CANCER, BIG DATA, PHARMACOLOGY, BIOLOGY, GENERATION, MECHANISMS, MODELS, TOOLS, Humans, Translational Medical Research, Decision Support Systems, Clinical, Systems Analysis, Biomedical Research",

author = "Rolf Apweiler and Tim Beissbarth and Berthold, {Michael R.} and Nils Bluethgen and Yvonne Burmeister and Olaf Dammann and Andreas Deutsch and Friedrich Feuerhake and Andre Franke and Jan Hasenauer and Steve Hoffmann and Thomas Hoefer and Jansen, {Peter L. M.} and Lars Kaderali and Ursula Klingmueller and Ina Koch and Oliver Kohlbacher and Lars Kuepfer and Frank Lammert and Dieter Maier and Nico Pfeifer and Nicole Radde and Markus Rehm and Ingo Roeder and Julio Saez-Rodriguez and Ulrich Sax and Bernd Schmeck and Andreas Schuppert and Bernd Seilheimer and Theis, {Fabian J.} and Julio Vera and Olaf Wolkenhauer",

year = "2018",

month = mar,

day = "2",

doi = "10.1038/emm.2017.290",

language = "English",

volume = "50",

journal = "Experimental and Molecular Medicine",

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Apweiler, R, Beissbarth, T, Berthold, MR, Bluethgen, N, Burmeister, Y, Dammann, O, Deutsch, A, Feuerhake, F, Franke, A, Hasenauer, J, Hoffmann, S, Hoefer, T, Jansen, PLM, Kaderali, L, Klingmueller, U, Koch, I, Kohlbacher, O, Kuepfer, L, Lammert, F, Maier, D, Pfeifer, N, Radde, N, Rehm, M, Roeder, I, Saez-Rodriguez, J, Sax, U, Schmeck, B, Schuppert, A, Seilheimer, B, Theis, FJ, Vera, J & Wolkenhauer, O 2018, 'Whither systems medicine?', Experimental and Molecular Medicine, vol. 50, no. 3, 453. https://doi.org/10.1038/emm.2017.290