TY - JOUR
T1 - Whither systems medicine?
AU - Apweiler, Rolf
AU - Beissbarth, Tim
AU - Berthold, Michael R.
AU - Bluethgen, Nils
AU - Burmeister, Yvonne
AU - Dammann, Olaf
AU - Deutsch, Andreas
AU - Feuerhake, Friedrich
AU - Franke, Andre
AU - Hasenauer, Jan
AU - Hoffmann, Steve
AU - Hoefer, Thomas
AU - Jansen, Peter L. M.
AU - Kaderali, Lars
AU - Klingmueller, Ursula
AU - Koch, Ina
AU - Kohlbacher, Oliver
AU - Kuepfer, Lars
AU - Lammert, Frank
AU - Maier, Dieter
AU - Pfeifer, Nico
AU - Radde, Nicole
AU - Rehm, Markus
AU - Roeder, Ingo
AU - Saez-Rodriguez, Julio
AU - Sax, Ulrich
AU - Schmeck, Bernd
AU - Schuppert, Andreas
AU - Seilheimer, Bernd
AU - Theis, Fabian J.
AU - Vera, Julio
AU - Wolkenhauer, Olaf
PY - 2018/3/2
Y1 - 2018/3/2
N2 - New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.
AB - New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.
KW - SINGLE-CELL ANALYSIS
KW - COLORECTAL-CANCER
KW - BIG DATA
KW - PHARMACOLOGY
KW - BIOLOGY
KW - GENERATION
KW - MECHANISMS
KW - MODELS
KW - TOOLS
KW - Humans
KW - Translational Medical Research
KW - Decision Support Systems, Clinical
KW - Systems Analysis
KW - Biomedical Research
U2 - 10.1038/emm.2017.290
DO - 10.1038/emm.2017.290
M3 - (Systematic) Review article
C2 - 29497170
SN - 1226-3613
VL - 50
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 3
M1 - 453
ER -