Whipple's disease: a difficult diagnosis?

F.P.J. Peters*, E.A. Elbrecht, R.S.M.E. Wouters, L.G.B. Engels, R.W. Stockbrugger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Whipple's disease: a difficult diagnosis?

Peters FP, Elbrecht EA, Wouters RS, Engels LG, Stockbrugger RW.

Department of Gastroenterology, University Hospital Maastricht, Netherlands.

We present 3 patients with Whipple's disease all characterized by a longstanding prodromal period with progressive weight loss, diarrhoea, lymphadenitis and arthralgia or arthritis. Sarcoid-like Whipple's disease was diagnosed in one patient. He was treated with antibiotics. Initially his condition improved; however, a cerebral relapse developed which was treated successfully by ceftriaxone and cefixime. Extraintestinal Whipple's disease (lymph node localisation) was diagnosed in another patient treated successfully with antibiotics. A third case of Whipple's disease was unexpectedly diagnosed by laparotomy and partial small bowel resection. He was not treated till 2 years later with tetracycline. After 1 year of treatment his condition had improved.

Publication Types:
Case Reports
Review, Tutorial
Original languageEnglish
Pages (from-to)106-111
JournalNetherlands Journal of Medicine
Publication statusPublished - 1 Jan 1996


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