Whipple's disease: a difficult diagnosis?

F.P.J. Peters, E.A. Elbrecht, R.S.M.E. Wouters, L.G.B. Engels, R.W. Stockbrugger

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Whipple's disease: a difficult diagnosis?

Peters FP, Elbrecht EA, Wouters RS, Engels LG, Stockbrugger RW.

Department of Gastroenterology, University Hospital Maastricht, Netherlands.

We present 3 patients with Whipple's disease all characterized by a longstanding prodromal period with progressive weight loss, diarrhoea, lymphadenitis and arthralgia or arthritis. Sarcoid-like Whipple's disease was diagnosed in one patient. He was treated with antibiotics. Initially his condition improved; however, a cerebral relapse developed which was treated successfully by ceftriaxone and cefixime. Extraintestinal Whipple's disease (lymph node localisation) was diagnosed in another patient treated successfully with antibiotics. A third case of Whipple's disease was unexpectedly diagnosed by laparotomy and partial small bowel resection. He was not treated till 2 years later with tetracycline. After 1 year of treatment his condition had improved.

Publication Types:
Case Reports
Review
Review, Tutorial
Original languageEnglish
Pages (from-to)106-111
JournalNetherlands Journal of Medicine
Volume49
DOIs
Publication statusPublished - 1 Jan 1996

Cite this

Peters, F. P. J., Elbrecht, E. A., Wouters, R. S. M. E., Engels, L. G. B., & Stockbrugger, R. W. (1996). Whipple's disease: a difficult diagnosis? Netherlands Journal of Medicine, 49, 106-111. https://doi.org/10.1016/0300-2977(96)00018-6