Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial

Parvin Tajik*, Linda van Wyk, Kim E. Boers, Saskia le Cessie, Mohammad Hadi Zafarmand, Frans Roumen, Joris A. M. van der Post, Martina Porath, Maria G. van Pampus, Marc E. A. Spaanderdami, Anneke Kwee, Johannes J. Duvekot, Henk A. Bremer, Friso M. C. Delemarre, Kitty W. M. Bloemenkamp, Christianne J. M. de Groot, Christine Willekes, Jan M. M. van Lith, Patrick M. Bossuyt, Ben W. J. MolSicco A. Scherjon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could identify IUGR fetuses who would benefit from early labour induction. Study design: The DIGITAT trial was a multicenter, parallel and open-label randomised controlled trial in women who had a singleton pregnancy beyond 36 + 0 weeks' gestation with suspected IUGR (n = 650). Women had been randomly allocated to either labour induction or expectant monitoring. The primary outcome was a composite measure of adverse neonatal outcome, defined as neonatal death before hospital discharge, Apgar score
Original languageEnglish
Pages (from-to)20-25
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Publication statusPublished - Jan 2014


  • Intrauterine growth restriction (IUGR)
  • Labour induction
  • Expectant monitoring
  • Treatment selection markers

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