Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han

Lili Hu; Handan Tan; Qingfeng Cao; Gangxiang Yuan; Changwei Huang; Guannan Su; Aize Kijlstra; Peizeng Yang

doi:10.1016/j.exer.2020.108045

Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han

Lili Hu, Handan Tan, Qingfeng Cao, Gangxiang Yuan, Changwei Huang, Guannan Su, Aize Kijlstra, Peizeng Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX (R) technology. Data were analyzed using a Chi-square (chi 2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD (Pc = 0.013, OR = 1.233, 95% CI = 1.103-1.379: Pc = 0.013, OR = 0.811, 95% CI = 0.725-0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population.

Original language	English
Article number	108045
Number of pages	6
Journal	Experimental Eye Research
Volume	196
DOIs	https://doi.org/10.1016/j.exer.2020.108045
Publication status	Published - Jul 2020

Keywords

Behcet's disease
Single nucleotide polymorphism
TNFSF
TNFRSF
Immune response
Autoinflammatory disease
Immunogenetics
NECROSIS-FACTOR RECEPTOR-1
GENOME-WIDE ASSOCIATION
GENE POLYMORPHISMS
ATHEROSCLEROSIS
INFLAMMATION
RESPONSES
LOCI

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10.1016/j.exer.2020.108045

Cite this

@article{71d5a8a012f140d494243ccc0ae6e050,

title = "Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han",

abstract = "The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX (R) technology. Data were analyzed using a Chi-square (chi 2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD (Pc = 0.013, OR = 1.233, 95% CI = 1.103-1.379: Pc = 0.013, OR = 0.811, 95% CI = 0.725-0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population.",

keywords = "Behcet's disease, Single nucleotide polymorphism, TNFSF, TNFRSF, Immune response, Autoinflammatory disease, Immunogenetics, NECROSIS-FACTOR RECEPTOR-1, GENOME-WIDE ASSOCIATION, GENE POLYMORPHISMS, ATHEROSCLEROSIS, INFLAMMATION, RESPONSES, LOCI",

author = "Lili Hu and Handan Tan and Qingfeng Cao and Gangxiang Yuan and Changwei Huang and Guannan Su and Aize Kijlstra and Peizeng Yang",

note = "Funding Information: This study was supported by National Natural Science Foundation Key Program ( 81930023 ), Natural Science Foundation Major International (Regional) Joint Research Project ( 81720108009 ), Chongqing Outstanding Scientists Project (2019) , Chongqing Key Laboratory of Ophthalmology (CSTC , 2008CA5003 ), Chongqing Science & Technology Platform and Base Construction Program ( cstc2014pt-sy10002 ) and the Chongqing Chief Medical Scientist Project (2018). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jul,

doi = "10.1016/j.exer.2020.108045",

language = "English",

volume = "196",

journal = "Experimental Eye Research",

issn = "0014-4835",

publisher = "Elsevier Science",

}

TY - JOUR

T1 - Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han

AU - Hu, Lili

AU - Tan, Handan

AU - Cao, Qingfeng

AU - Yuan, Gangxiang

AU - Huang, Changwei

AU - Su, Guannan

AU - Kijlstra, Aize

AU - Yang, Peizeng

N1 - Funding Information: This study was supported by National Natural Science Foundation Key Program ( 81930023 ), Natural Science Foundation Major International (Regional) Joint Research Project ( 81720108009 ), Chongqing Outstanding Scientists Project (2019) , Chongqing Key Laboratory of Ophthalmology (CSTC , 2008CA5003 ), Chongqing Science & Technology Platform and Base Construction Program ( cstc2014pt-sy10002 ) and the Chongqing Chief Medical Scientist Project (2018). Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/7

Y1 - 2020/7

N2 - The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX (R) technology. Data were analyzed using a Chi-square (chi 2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD (Pc = 0.013, OR = 1.233, 95% CI = 1.103-1.379: Pc = 0.013, OR = 0.811, 95% CI = 0.725-0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population.

AB - The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX (R) technology. Data were analyzed using a Chi-square (chi 2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD (Pc = 0.013, OR = 1.233, 95% CI = 1.103-1.379: Pc = 0.013, OR = 0.811, 95% CI = 0.725-0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population.

KW - Behcet's disease

KW - Single nucleotide polymorphism

KW - TNFSF

KW - TNFRSF

KW - Immune response

KW - Autoinflammatory disease

KW - Immunogenetics

KW - NECROSIS-FACTOR RECEPTOR-1

KW - GENOME-WIDE ASSOCIATION

KW - GENE POLYMORPHISMS

KW - ATHEROSCLEROSIS

KW - INFLAMMATION

KW - RESPONSES

KW - LOCI

U2 - 10.1016/j.exer.2020.108045

DO - 10.1016/j.exer.2020.108045

M3 - Article

C2 - 32389622

SN - 0014-4835

VL - 196

JO - Experimental Eye Research

JF - Experimental Eye Research

M1 - 108045

ER -