Waddlia chondrophila and Chlamydia trachomatis antibodies in screening infertile women for tubal pathology

S. P. Verweij*, C. Kebbi-Beghdadi, J. A. Land, S. Ouburg, S. A. Morre, G. Greub

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)

Abstract

Since Waddlia chondrophila is closely related to Chlamydia trachomatis, we hypothesise that W. chondrophila may also be associated with tubal factor infertility (TFI) in women, a major complication of chronic C. trachomatis infection. Five hundred twenty serum samples were tested for anti-Waddlia antibodies by ELISA. Among the 520 investigated women, a total number of 142 (27.3%) has had laparoscopic diagnosis performed, and were either classified TFI positive or negative. Presence of high titres of W. chondrophila antibodies was linked to TFI (p <0.0001; OR: 7.5; 95% CI: 3.3-17). Moreover, antibody positivity to both W. chondrophila and C. trachomatis-MOMP was strongly associated with TFI (p <0.0001; OR: 21; 95% CI: 3.8-12E1). This association was much stronger than the statistical association of C. trachomatis-MOMP antibodies only (p <0.0001; OR: 7.1; 95% CI: 3.7-14), suggesting that co-infection with W. chondrophila and C. trachomatis may lead to more severe reproductive sequelae and immune responses than single infection with either Chlamydiales members.
Original languageEnglish
Pages (from-to)745-748
JournalMicrobes and Infection
Volume17
Issue number11-12
DOIs
Publication statusPublished - 2015

Keywords

  • Waddlia chondrophila
  • Chlamydia trachomatis
  • Tubal factor infertility
  • TFI
  • Screening

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