Waddlia chondrophila and Chlamydia trachomatis antibodies in screening infertile women for tubal pathology

S. P. Verweij*, C. Kebbi-Beghdadi, J. A. Land, S. Ouburg, S. A. Morre, G. Greub

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Since Waddlia chondrophila is closely related to Chlamydia trachomatis, we hypothesise that W. chondrophila may also be associated with tubal factor infertility (TFI) in women, a major complication of chronic C. trachomatis infection. Five hundred twenty serum samples were tested for anti-Waddlia antibodies by ELISA. Among the 520 investigated women, a total number of 142 (27.3%) has had laparoscopic diagnosis performed, and were either classified TFI positive or negative. Presence of high titres of W. chondrophila antibodies was linked to TFI (p <0.0001; OR: 7.5; 95% CI: 3.3-17). Moreover, antibody positivity to both W. chondrophila and C. trachomatis-MOMP was strongly associated with TFI (p <0.0001; OR: 21; 95% CI: 3.8-12E1). This association was much stronger than the statistical association of C. trachomatis-MOMP antibodies only (p <0.0001; OR: 7.1; 95% CI: 3.7-14), suggesting that co-infection with W. chondrophila and C. trachomatis may lead to more severe reproductive sequelae and immune responses than single infection with either Chlamydiales members.
Original languageEnglish
Pages (from-to)745-748
JournalMicrobes and Infection
Volume17
Issue number11-12
DOIs
Publication statusPublished - 2015

Keywords

  • Waddlia chondrophila
  • Chlamydia trachomatis
  • Tubal factor infertility
  • TFI
  • Screening

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