Vitamin D supplementation in multiple sclerosis: an expert opinion based on the review of current evidence

R. Boltjes, S. Knippenberg, O. Gerlach, R. Hupperts, J. Damoiseaux*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Introduction Vitamin D has long been known for its immune-modulating effects, next to its function in calcium metabolism. As a consequence, poor vitamin D status has been associated with many diseases including multiple sclerosis (MS). Epidemiological studies suggest an association between a poor vitamin D status and development of MS and a poor vitamin D status is associated with more relapses and faster progression after patients are diagnosed with MS. Area's covered The aim of the authors was to review the role of vitamin D supplementation in the treatment of MS. Pubmed was used to review literature with a focus of vitamin D supplementation trials and meta-analyses in MS. Expert opinion There is no solid evidence to support the application of vitamin D therapy, based on current available supplementation trials, although there are some promising results in the clinically isolated syndrome (CIS) patients and young MS patients early after initial diagnosis. The authors recommend further larger clinical trials with selected patient groups, preferable CIS patients and young patients at the time of diagnosis, using vitamin D-3 supplements to reach a 100 nmol/l level, to further investigate the effects of vitamin D supplementation in MS.
Original languageEnglish
Pages (from-to)715-725
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume21
Issue number6
DOIs
Publication statusPublished - 3 Jun 2021

Keywords

  • Vitamin D
  • Multiple Sclerosis
  • 25-hydroxyvitamin D
  • vitamin D supplementation
  • RANDOMIZED CONTROLLED-TRIAL
  • DOUBLE-BLIND
  • RELAPSE RATE
  • 25-HYDROXYVITAMIN-D LEVELS
  • SERUM 25-HYDROXYVITAMIN-D
  • DISEASE PROGRESSION
  • OPTIC NEURITIS
  • IMMUNE-SYSTEM
  • UV-RADIATION
  • LESION LOAD

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