Abstract
Vitamin D seems to be implicated in the pathophysiology of autoimmune disorders as a natural immune modulator. Beneficial effects of vitamin D have been associated with different cells of the immune system; however, thus far, B cells seem to be somewhat neglected. In this paper, we describe the possible direct effects of vitamin D on B cells, with a focus on antibody production and the more recently identified regulatory B (Breg ) cells. B cells upregulate the vitamin D receptor (VDR) upon activation. Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D. B cells, therefore, may participate in vitamin D-mediated immune homeostasis, including plasma cell generation. Whether or not other B cell subsets, such as Breg cells, are equally responsive to vitamin D remains to be established.
Original language | English |
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Pages (from-to) | 84-91 |
Number of pages | 8 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1317 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Keywords
- vitamin D
- B cell function
- autoimmune diseases
- regulatory B cell
- interleukin-10
- REGULATORY T-CELLS
- MULTIPLE-SCLEROSIS
- 1,25-DIHYDROXYVITAMIN D-3
- IMMUNOGLOBULIN PRODUCTION
- IGE PRODUCTION
- D DEFICIENCY
- DISEASE
- IL-10
- DIFFERENTIATION
- INHIBITION