Visual stimuli modulate frontal oscillatory rhythms in a cortically blind patient: Evidence for top-down visual processing

Eda Tipura, Alan J. Pegna, Beatrice de Gelder, Olivier Renaud

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient.

METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants.

RESULTS: Post stimulus oscillatory modulations (synchronisation in theta and alpha frequency bands) of both intact and scrambled faces at frontal scalp sites were observed in TN. These modulations were different for correct and incorrect responses. A more important increase in the theta band for incorrect responses was observed. The oscillatory rhythms highlighted in blindsight and in frontal regions differ from the ones observed in control participants.

CONCLUSION: Despite the destruction of the visual cortex, oscillatory rhythms are not cancelled out but are shifted to anterior regions, revealing the activity of an alternate pathway for residual visual function.

SIGNIFICANCE: The results provide evidence for a top-down cognitive control process in blindsight.

Original languageEnglish
Pages (from-to)770-779
Number of pages10
JournalClinical Neurophysiology
Volume128
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Blindness, Cortical
  • Case-Control Studies
  • Frontal Lobe
  • Humans
  • Male
  • Middle Aged
  • Theta Rhythm
  • Visual Pathways
  • Visual Perception
  • Case Reports
  • Journal Article
  • THETA ACTIVITY
  • Frontal midline theta rhythm
  • Blindsight
  • HUMAN SCALP
  • Frontal cortex
  • STRIATE CORTEX
  • EMOTIONAL EXPRESSIONS
  • EEG
  • FUSIFORM FACE AREA
  • MEMORY TASK
  • Event-related spectral perturbation
  • SYNCHRONIZATION
  • Vision
  • HUMAN EXTRASTRIATE CORTEX
  • ALPHA-BAND

Cite this