Visual stimuli modulate frontal oscillatory rhythms in a cortically blind patient: Evidence for top-down visual processing

Eda Tipura, Alan J. Pegna, Beatrice de Gelder, Olivier Renaud

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient.

METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants.

RESULTS: Post stimulus oscillatory modulations (synchronisation in theta and alpha frequency bands) of both intact and scrambled faces at frontal scalp sites were observed in TN. These modulations were different for correct and incorrect responses. A more important increase in the theta band for incorrect responses was observed. The oscillatory rhythms highlighted in blindsight and in frontal regions differ from the ones observed in control participants.

CONCLUSION: Despite the destruction of the visual cortex, oscillatory rhythms are not cancelled out but are shifted to anterior regions, revealing the activity of an alternate pathway for residual visual function.

SIGNIFICANCE: The results provide evidence for a top-down cognitive control process in blindsight.

Original languageEnglish
Pages (from-to)770-779
Number of pages10
JournalClinical Neurophysiology
Volume128
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Blindness, Cortical
  • Case-Control Studies
  • Frontal Lobe
  • Humans
  • Male
  • Middle Aged
  • Theta Rhythm
  • Visual Pathways
  • Visual Perception
  • Case Reports
  • Journal Article
  • THETA ACTIVITY
  • Frontal midline theta rhythm
  • Blindsight
  • HUMAN SCALP
  • Frontal cortex
  • STRIATE CORTEX
  • EMOTIONAL EXPRESSIONS
  • EEG
  • FUSIFORM FACE AREA
  • MEMORY TASK
  • Event-related spectral perturbation
  • SYNCHRONIZATION
  • Vision
  • HUMAN EXTRASTRIATE CORTEX
  • ALPHA-BAND

Cite this

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title = "Visual stimuli modulate frontal oscillatory rhythms in a cortically blind patient: Evidence for top-down visual processing",
abstract = "OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient.METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants.RESULTS: Post stimulus oscillatory modulations (synchronisation in theta and alpha frequency bands) of both intact and scrambled faces at frontal scalp sites were observed in TN. These modulations were different for correct and incorrect responses. A more important increase in the theta band for incorrect responses was observed. The oscillatory rhythms highlighted in blindsight and in frontal regions differ from the ones observed in control participants.CONCLUSION: Despite the destruction of the visual cortex, oscillatory rhythms are not cancelled out but are shifted to anterior regions, revealing the activity of an alternate pathway for residual visual function.SIGNIFICANCE: The results provide evidence for a top-down cognitive control process in blindsight.",
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author = "Eda Tipura and Pegna, {Alan J.} and {de Gelder}, Beatrice and Olivier Renaud",
note = "Copyright {\circledC} 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
year = "2017",
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Visual stimuli modulate frontal oscillatory rhythms in a cortically blind patient : Evidence for top-down visual processing. / Tipura, Eda; Pegna, Alan J.; de Gelder, Beatrice; Renaud, Olivier.

In: Clinical Neurophysiology, Vol. 128, No. 5, 05.2017, p. 770-779.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Visual stimuli modulate frontal oscillatory rhythms in a cortically blind patient

T2 - Evidence for top-down visual processing

AU - Tipura, Eda

AU - Pegna, Alan J.

AU - de Gelder, Beatrice

AU - Renaud, Olivier

N1 - Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2017/5

Y1 - 2017/5

N2 - OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient.METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants.RESULTS: Post stimulus oscillatory modulations (synchronisation in theta and alpha frequency bands) of both intact and scrambled faces at frontal scalp sites were observed in TN. These modulations were different for correct and incorrect responses. A more important increase in the theta band for incorrect responses was observed. The oscillatory rhythms highlighted in blindsight and in frontal regions differ from the ones observed in control participants.CONCLUSION: Despite the destruction of the visual cortex, oscillatory rhythms are not cancelled out but are shifted to anterior regions, revealing the activity of an alternate pathway for residual visual function.SIGNIFICANCE: The results provide evidence for a top-down cognitive control process in blindsight.

AB - OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient.METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants.RESULTS: Post stimulus oscillatory modulations (synchronisation in theta and alpha frequency bands) of both intact and scrambled faces at frontal scalp sites were observed in TN. These modulations were different for correct and incorrect responses. A more important increase in the theta band for incorrect responses was observed. The oscillatory rhythms highlighted in blindsight and in frontal regions differ from the ones observed in control participants.CONCLUSION: Despite the destruction of the visual cortex, oscillatory rhythms are not cancelled out but are shifted to anterior regions, revealing the activity of an alternate pathway for residual visual function.SIGNIFICANCE: The results provide evidence for a top-down cognitive control process in blindsight.

KW - Blindness, Cortical

KW - Case-Control Studies

KW - Frontal Lobe

KW - Humans

KW - Male

KW - Middle Aged

KW - Theta Rhythm

KW - Visual Pathways

KW - Visual Perception

KW - Case Reports

KW - Journal Article

KW - THETA ACTIVITY

KW - Frontal midline theta rhythm

KW - Blindsight

KW - HUMAN SCALP

KW - Frontal cortex

KW - STRIATE CORTEX

KW - EMOTIONAL EXPRESSIONS

KW - EEG

KW - FUSIFORM FACE AREA

KW - MEMORY TASK

KW - Event-related spectral perturbation

KW - SYNCHRONIZATION

KW - Vision

KW - HUMAN EXTRASTRIATE CORTEX

KW - ALPHA-BAND

U2 - 10.1016/j.clinph.2017.02.009

DO - 10.1016/j.clinph.2017.02.009

M3 - Article

C2 - 28319878

VL - 128

SP - 770

EP - 779

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 5

ER -