TY - JOUR
T1 - Vessel-Associated Immune Cells in Cerebrovascular Diseases
T2 - From Perivascular Macrophages to Vessel-Associated Microglia
AU - Koizumi, Takashi
AU - Kerkhofs, Danielle
AU - Mizuno, Toshiki
AU - Steinbusch, Harry W. M.
AU - Foulquier, Sebastien
N1 - Funding Information:
SF has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 666881 SVDs@target and from Netherlands CardioVascular Research Initiative (CVON 2012-06 Heart Brain Connection).
Publisher Copyright:
© Copyright © 2019 Koizumi, Kerkhofs, Mizuno, Steinbusch and Foulquier.
PY - 2019/12/4
Y1 - 2019/12/4
N2 - Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features of the blood-brain barrier. Cerebrovascular dysfunction is therefore seen as a detrimental factor for the initiation of several central nervous system (CNS) disorders, such as stroke, cerebral small vessel disease (cSVD), and Alzheimer's disease. The main working hypothesis linking cerebrovascular dysfunction to brain disorders includes the contribution of neuroinflammation. While our knowledge on microglia cells - the brain-resident immune cells - has been increasing in the last decades, the specific populations of microglia and macrophages surrounding brain vessels, vessel-associated microglia (VAM), and perivascular macrophages (PVMs), respectively, have been overlooked. This review aims to summarize the knowledge gathered on VAM and PVMs, to discuss existing knowledge gaps of importance for later studies and to summarize evidences for their contribution to cerebrovascular dysfunction.
AB - Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features of the blood-brain barrier. Cerebrovascular dysfunction is therefore seen as a detrimental factor for the initiation of several central nervous system (CNS) disorders, such as stroke, cerebral small vessel disease (cSVD), and Alzheimer's disease. The main working hypothesis linking cerebrovascular dysfunction to brain disorders includes the contribution of neuroinflammation. While our knowledge on microglia cells - the brain-resident immune cells - has been increasing in the last decades, the specific populations of microglia and macrophages surrounding brain vessels, vessel-associated microglia (VAM), and perivascular macrophages (PVMs), respectively, have been overlooked. This review aims to summarize the knowledge gathered on VAM and PVMs, to discuss existing knowledge gaps of importance for later studies and to summarize evidences for their contribution to cerebrovascular dysfunction.
KW - cerebrovascular dysfunction
KW - neuroinflammation
KW - cerebral small vessel disease
KW - vascular cognitive impairment and dementia
KW - microglia
KW - macrophages
KW - hypertension
KW - stroke
KW - CENTRAL-NERVOUS-SYSTEM
KW - PHYSIOLOGICAL CONDITIONS
KW - RECEPTOR
KW - MOUSE
KW - EXPRESSION
KW - HEALTH
KW - CNS
KW - HETEROGENEITY
KW - IDENTITY
KW - REVEALS
U2 - 10.3389/fnins.2019.01291
DO - 10.3389/fnins.2019.01291
M3 - (Systematic) Review article
C2 - 31866808
SN - 1662-453X
VL - 13
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
M1 - 1291
ER -