Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report

Hilde M. H. Braakman*, Jan Lodder, Alida A Postma, Lambert F. R. Span, Werner H. Mess

*Corresponding author for this work

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Background: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial. Case presentation: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment. Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved. Conclusions: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.
Original languageEnglish
Pages (from-to)30
JournalBMC Neurology
Publication statusPublished - 11 May 2010

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