Abstract
This dissertation examines the role of smooth muscle cells (VSMC) in the development of vascular calcification and atherosclerosis. Smoking causes a significant increase in microcalcification, which is the most dangerous form of vascular calcification. A nicotinic receptor causes increased oxidative stress and exome secretion in the smooth muscle cells. The vitamin K-dependent protein Ucma/GRP appears to protect against vascular calcification by inhibiting oestrogen differentiation in smooth muscle cells. Smooth muscle cells play a protective role in the development and progression of atherosclerosis. This finding may have far-reaching consequences for modern techniques used to treat blocked arteries.
Original language | English |
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Awarding Institution |
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Award date | 1 Dec 2017 |
Place of Publication | Maastricht |
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Print ISBNs | 9789462957671 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- smooth muscle cells (VSMC)
- vascular calcification
- atherosclerosis
- Ucma/GRP
- vitamin K