Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies

Yvonne Doring; Heidi Noels; Emiel P. C. van der Vorst; Carlos Neideck; Virginia Egea; Maik Drechsler; Manuela Mandl; Lukas Pawig; Yvonne Jansen; Katrin Schroeder; Kiril Bidzhekov; Remco T. A. Megens; Wendy Theelen; Barbara M. Klinkhammer; Peter Boor; Leon Schurgers; Rick van Gorp; Christian Ries; Pascal J. H. Kusters; Allard van der Wal; Tilman M. Hackeng; Gabor Gaebel; Ralf P. Brandes; Oliver Soehnlein; Esther Lutgens; Dietmar Vestweber; Daniel Teupser; Lesca M. Holdt; Daniel J. Rader; Danish Saleheen; Christian Weber

doi:10.1161/CIRCULATIONAHA.117.027646

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies

Yvonne Doring, Heidi Noels, Emiel P. C. van der Vorst, Carlos Neideck, Virginia Egea, Maik Drechsler, Manuela Mandl, Lukas Pawig, Yvonne Jansen, Katrin Schroeder, Kiril Bidzhekov, Remco T. A. Megens, Wendy Theelen, Barbara M. Klinkhammer, Peter Boor, Leon Schurgers, Rick van Gorp, Christian Ries, Pascal J. H. Kusters, Allard van der WalTilman M. Hackeng, Gabor Gaebel, Ralf P. Brandes, Oliver Soehnlein, Esther Lutgens, Dietmar Vestweber, Daniel Teupser, Lesca M. Holdt, Daniel J. Rader, Danish Saleheen, Christian Weber^*

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	388-403
Number of pages	39
Journal	Circulation
Volume	136
Issue number	4
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.117.027646
Publication status	Published - 25 Jul 2017

Keywords

atherosclerosis
cadherins
endothelial cells
receptors, CXCR4
permeability
smooth muscle cell phenotype
WNT signaling pathway
SMOOTH-MUSCLE-CELLS
CHEMOKINE RECEPTOR CXCR4
MACROPHAGE-LIKE CELLS
E-DEFICIENT MICE
VE-CADHERIN
MYOCARDIAL-INFARCTION
CHOLESTEROL EFFLUX
PROMOTES ATHEROSCLEROSIS
NEOINTIMAL HYPERPLASIA
CARDIOVASCULAR-DISEASE

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10.1161/CIRCULATIONAHA.117.027646

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Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroeder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., ... Weber, C. (2017). Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies. Circulation, 136(4), 388-403. https://doi.org/10.1161/CIRCULATIONAHA.117.027646

Doring, Yvonne ; Noels, Heidi ; van der Vorst, Emiel P. C. ; Neideck, Carlos ; Egea, Virginia ; Drechsler, Maik ; Mandl, Manuela ; Pawig, Lukas ; Jansen, Yvonne ; Schroeder, Katrin ; Bidzhekov, Kiril ; Megens, Remco T. A. ; Theelen, Wendy ; Klinkhammer, Barbara M. ; Boor, Peter ; Schurgers, Leon ; van Gorp, Rick ; Ries, Christian ; Kusters, Pascal J. H. ; van der Wal, Allard ; Hackeng, Tilman M. ; Gaebel, Gabor ; Brandes, Ralf P. ; Soehnlein, Oliver ; Lutgens, Esther ; Vestweber, Dietmar ; Teupser, Daniel ; Holdt, Lesca M. ; Rader, Daniel J. ; Saleheen, Danish ; Weber, Christian. / Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies. In: Circulation. 2017 ; Vol. 136, No. 4. pp. 388-403.

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title = "Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies",

keywords = "atherosclerosis, cadherins, endothelial cells, receptors, CXCR4, permeability, smooth muscle cell phenotype, WNT signaling pathway, SMOOTH-MUSCLE-CELLS, CHEMOKINE RECEPTOR CXCR4, MACROPHAGE-LIKE CELLS, E-DEFICIENT MICE, VE-CADHERIN, MYOCARDIAL-INFARCTION, CHOLESTEROL EFFLUX, PROMOTES ATHEROSCLEROSIS, NEOINTIMAL HYPERPLASIA, CARDIOVASCULAR-DISEASE",

author = "Yvonne Doring and Heidi Noels and {van der Vorst}, {Emiel P. C.} and Carlos Neideck and Virginia Egea and Maik Drechsler and Manuela Mandl and Lukas Pawig and Yvonne Jansen and Katrin Schroeder and Kiril Bidzhekov and Megens, {Remco T. A.} and Wendy Theelen and Klinkhammer, {Barbara M.} and Peter Boor and Leon Schurgers and {van Gorp}, Rick and Christian Ries and Kusters, {Pascal J. H.} and {van der Wal}, Allard and Hackeng, {Tilman M.} and Gabor Gaebel and Brandes, {Ralf P.} and Oliver Soehnlein and Esther Lutgens and Dietmar Vestweber and Daniel Teupser and Holdt, {Lesca M.} and Rader, {Daniel J.} and Danish Saleheen and Christian Weber",

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doi = "10.1161/CIRCULATIONAHA.117.027646",

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Doring, Y, Noels, H, van der Vorst, EPC, Neideck, C, Egea, V, Drechsler, M, Mandl, M, Pawig, L, Jansen, Y, Schroeder, K, Bidzhekov, K, Megens, RTA, Theelen, W, Klinkhammer, BM, Boor, P, Schurgers, L, van Gorp, R, Ries, C, Kusters, PJH, van der Wal, A, Hackeng, TM, Gaebel, G, Brandes, RP, Soehnlein, O, Lutgens, E, Vestweber, D, Teupser, D, Holdt, LM, Rader, DJ, Saleheen, D & Weber, C 2017, 'Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies', Circulation, vol. 136, no. 4, pp. 388-403. https://doi.org/10.1161/CIRCULATIONAHA.117.027646

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies. / Doring, Yvonne; Noels, Heidi; van der Vorst, Emiel P. C.; Neideck, Carlos; Egea, Virginia; Drechsler, Maik; Mandl, Manuela; Pawig, Lukas; Jansen, Yvonne; Schroeder, Katrin; Bidzhekov, Kiril; Megens, Remco T. A.; Theelen, Wendy; Klinkhammer, Barbara M.; Boor, Peter; Schurgers, Leon; van Gorp, Rick; Ries, Christian; Kusters, Pascal J. H.; van der Wal, Allard; Hackeng, Tilman M.; Gaebel, Gabor; Brandes, Ralf P.; Soehnlein, Oliver; Lutgens, Esther; Vestweber, Dietmar; Teupser, Daniel; Holdt, Lesca M.; Rader, Daniel J.; Saleheen, Danish; Weber, Christian.

In: Circulation, Vol. 136, No. 4, 25.07.2017, p. 388-403.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity Evidence From Mouse and Human Studies

AU - Doring, Yvonne

AU - Noels, Heidi

AU - van der Vorst, Emiel P. C.

AU - Neideck, Carlos

AU - Egea, Virginia

AU - Drechsler, Maik

AU - Mandl, Manuela

AU - Pawig, Lukas

AU - Jansen, Yvonne

AU - Schroeder, Katrin

AU - Bidzhekov, Kiril

AU - Megens, Remco T. A.

AU - Theelen, Wendy

AU - Klinkhammer, Barbara M.

AU - Boor, Peter

AU - Schurgers, Leon

AU - van Gorp, Rick

AU - Ries, Christian

AU - Kusters, Pascal J. H.

AU - van der Wal, Allard

AU - Hackeng, Tilman M.

AU - Gaebel, Gabor

AU - Brandes, Ralf P.

AU - Soehnlein, Oliver

AU - Lutgens, Esther

AU - Vestweber, Dietmar

AU - Teupser, Daniel

AU - Holdt, Lesca M.

AU - Rader, Daniel J.

AU - Saleheen, Danish

AU - Weber, Christian

PY - 2017/7/25

Y1 - 2017/7/25

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KW - cadherins

KW - endothelial cells

KW - receptors, CXCR4

KW - permeability

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KW - WNT signaling pathway

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KW - CHEMOKINE RECEPTOR CXCR4

KW - MACROPHAGE-LIKE CELLS

KW - E-DEFICIENT MICE

KW - VE-CADHERIN

KW - MYOCARDIAL-INFARCTION

KW - CHOLESTEROL EFFLUX

KW - PROMOTES ATHEROSCLEROSIS

KW - NEOINTIMAL HYPERPLASIA

KW - CARDIOVASCULAR-DISEASE

U2 - 10.1161/CIRCULATIONAHA.117.027646

DO - 10.1161/CIRCULATIONAHA.117.027646

M3 - Article

C2 - 28450349

VL - 136

SP - 388

EP - 403

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 4

ER -