TY - JOUR
T1 - Validation of the maximal cardiopulmonary exercise test in adolescents with major depressive disorder and comparison of cardiorespiratory fitness with sex- and age-related control values
AU - Wenzel, Charlotte
AU - Bongers, Bart Chateau
AU - Schlagheck, Marit Lea
AU - Reis, Daniela
AU - Reinhard, Franziska
AU - Schmidt, Peter
AU - Bernitzki, Stefan
AU - Oberste, Max
AU - Wunram, Heidrun Lioba
AU - Zimmer, Philipp
AU - Fricke, Oliver
N1 - Funding Information:
This study could only be conducted with financial support of the Marga and Walter Boll Foundation, the support of Prof. Jörg Dötsch, MD, (Department of Pediatrics, University Hospital of Cologne) and Prof. Konrad Brockmeier, MD, (Pediatric Cardiology, Heart Centre, University Hospital of Cologne, Cologne, Germany), as well as the work of the entire “Mood Vibes” doctoral students team (in alphabetic order): Fabian Abuhsin, Ralf Beccard, Louisa Belke, Sarah Damsch, Nils Grote, Michael Holder, Franziska Jänicke, Franziska Reinhard, Andrea Steffen, Till Thimme, Maxi Volk, Alischa Ziemendorff. This manuscript contains parts of a master and doctoral thesis by Franziska Reinhard.
Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - Endurance training has been shown to be effective in treating adolescents with major depressive disorder (MDD). To integrate endurance training into the therapeutic setting and the adolescents' daily lives, the current performance status of the adolescents should be accurately assessed. This study aims to examine adolescents with MDD concerning exhaustion criteria during a cardiopulmonary exercise test (CPET), as well as to compare the values obtained thereon with sex- and age-related control values. The study included a retrospective examination of exhaustion criteria ((i) oxygen consumption (V̇O
2) plateau, (ii) peak respiratory exchange ratio (RER
peak) > 1.0, (iii) peak heart rate (HR
peak) ≥ 95% of the age-predicted maximal HR, and (iv) peak blood lactate concentration (BLC
peak) > 8.0 mmol⋅L
−1) during a graded CPET on a cycle ergometer in adolescents with MDD (n = 57). Subsequently, maximal V̇O
2, peak minute ventilation, V̇O
2 at the first ventilatory threshold, and peak work rate of participants who met at least two of four criteria were compared with published control values using an independent-sample t-test. Thirty-three percent of the total population achieved a V̇O
2 plateau and 75% a RER
peak > 1.0. The HR and BLC criteria were met by 19% and 22%, respectively. T-test results revealed significant differences between adolescents with MDD and control values for all outcomes. Adolescents with MDD achieved between 56% and 83% of control values. Conclusions: The study shows that compared with control values, fewer adolescents with MDD achieve the exhaustion criteria on a CPET and adolescents with MDD have significantly lower cardiorespiratory fitness. Clinical trial registration: No. U1111-1145–1854. (Table presented.)
AB - Endurance training has been shown to be effective in treating adolescents with major depressive disorder (MDD). To integrate endurance training into the therapeutic setting and the adolescents' daily lives, the current performance status of the adolescents should be accurately assessed. This study aims to examine adolescents with MDD concerning exhaustion criteria during a cardiopulmonary exercise test (CPET), as well as to compare the values obtained thereon with sex- and age-related control values. The study included a retrospective examination of exhaustion criteria ((i) oxygen consumption (V̇O
2) plateau, (ii) peak respiratory exchange ratio (RER
peak) > 1.0, (iii) peak heart rate (HR
peak) ≥ 95% of the age-predicted maximal HR, and (iv) peak blood lactate concentration (BLC
peak) > 8.0 mmol⋅L
−1) during a graded CPET on a cycle ergometer in adolescents with MDD (n = 57). Subsequently, maximal V̇O
2, peak minute ventilation, V̇O
2 at the first ventilatory threshold, and peak work rate of participants who met at least two of four criteria were compared with published control values using an independent-sample t-test. Thirty-three percent of the total population achieved a V̇O
2 plateau and 75% a RER
peak > 1.0. The HR and BLC criteria were met by 19% and 22%, respectively. T-test results revealed significant differences between adolescents with MDD and control values for all outcomes. Adolescents with MDD achieved between 56% and 83% of control values. Conclusions: The study shows that compared with control values, fewer adolescents with MDD achieve the exhaustion criteria on a CPET and adolescents with MDD have significantly lower cardiorespiratory fitness. Clinical trial registration: No. U1111-1145–1854. (Table presented.)
KW - Aerobic fitness
KW - Control values
KW - Cycle ergometer
KW - Exhaustion criteria
KW - Maximal oxygen consumption
U2 - 10.1007/s00431-023-05304-6
DO - 10.1007/s00431-023-05304-6
M3 - Article
SN - 0340-6199
VL - 183
SP - 379
EP - 388
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 1
ER -