TY - JOUR
T1 - Validation of replacement questions for slowness and weakness to assess the Fried Phenotype
T2 - a cross-sectional study
AU - Van Der Elst, Michael C. J.
AU - Schoenmakers, Birgitte
AU - Veld, Linda P. M. Op Het
AU - Deroeck, Ellen E.
AU - van Der Vorst, Anne
AU - Schols, Jos M. G. A.
AU - De Lepeleire, Jan
AU - Kempen, Gertrudis I. J. M.
AU - D-SCOPE Consortium
N1 - Funding Information:
The D-SCOPE consortium is an international research consortium and is composed of researchers from Vrije Universiteit Brussel, Belgium (Dr. A.‐S. Smetcoren, Dr. S. Dury, Prof. Dr. L. De Donder, Prof. Dr. E. Dierckx, Dr. D. Lambotte, Dr. B. Fret, Dr. D. Duppen, Prof. Dr. M. Kardol, Prof. Dr. D. Verté); College University Ghent, Belgium (Dr. L. J. Hoeyberghs, Prof. Dr. N. De Witte); Universiteit Antwerpen, Belgium (Dr. E. E. De Roeck, Prof. Dr. S. Engelborghs, Prof. Dr. P. P. De Deyn); Katholieke Universiteit Leuven, Belgium (M. Van der Elst, Prof. Dr. J. De Lepeleire, Prof. Dr. B. Schoenmakers); and Maastricht University, the Netherlands (M. Van der Elst, Dr. A. van der Vorst, Dr. G. A. R. Zijlstra, Prof. Dr. G. I. J. M. Kempen, Prof. Dr. J. M. G. A. Schols). The authors warmly thank the older respondents who participated in the study. The data in Table 2 : descriptive statistics of the study sample (N = 196) has been originally published in BMC Geriatrics, reference: Van der Elst, M. C. J., Schoenmakers, B., Op het Veld, L. P. M. et al. Concordances and differences between a unidimensional and multidimensional assessment of frailty: a cross-sectional study. BMC Geriatr 19:346 (2019). 10.1186/s12877-019-1369-7. This article was distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/10
Y1 - 2020/10
N2 - Key summary pointsAim What is the overall concordance between FRIED-P and FRIED-Q? Findings The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity but a moderate sensitivity. Message The FRIED-Q can be used as a step in a sequential process to detect frailty in a large population.Purpose When screening large populations, performance-based measures can be difficult to conduct because they are time consuming and costly, and require well-trained assessors. The aim of the present study is to validate a set of questions replacing the performance-based measures slowness and weakness as part of the Fried frailty phenotype (FRIED-P). Methods A cross-sectional study was conducted among community-dwelling older adults (>= 60 years) in three Flemish municipalities. The Fried Phenotype (FRIED-P) was used to measure physical frailty. The two performance-based measures of the Fried Phenotype (slowness and weakness) were also measured by means of six substituting questions (FRIED-Q). These questions were validated through sensitivity, specificity, Cohen's kappa value, observed agreement, correlation analysis, and the area under the curve (AUC, ROC curve). Results 196 older adults participated. According to the FRIED-P, 19.5% of them were frail, 56.9% were pre-frail and 23.6% were non-frail. For slowness, the observed sensitivity was 47.0%, the specificity was 96.5% and the AUC was 0.717. For weakness, the sensitivity was 46.2%, the specificity was 83.7%, and the AUC was 0.649. The overall Spearman correlation between the FRIED-P and the FRIED-Q was r = 0.721 with an observed agreement of 76.6% (weighted linear kappa value = 0.663, quadratic kappa value = 0.738). Conclusions The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity, but a moderate sensitivity. This alternative operationalization of the Fried Phenotype-i.e., including six replacement questions instead of two performance-based tests-can be considered to apply as screening tool to screen physical frailty in large populations.
AB - Key summary pointsAim What is the overall concordance between FRIED-P and FRIED-Q? Findings The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity but a moderate sensitivity. Message The FRIED-Q can be used as a step in a sequential process to detect frailty in a large population.Purpose When screening large populations, performance-based measures can be difficult to conduct because they are time consuming and costly, and require well-trained assessors. The aim of the present study is to validate a set of questions replacing the performance-based measures slowness and weakness as part of the Fried frailty phenotype (FRIED-P). Methods A cross-sectional study was conducted among community-dwelling older adults (>= 60 years) in three Flemish municipalities. The Fried Phenotype (FRIED-P) was used to measure physical frailty. The two performance-based measures of the Fried Phenotype (slowness and weakness) were also measured by means of six substituting questions (FRIED-Q). These questions were validated through sensitivity, specificity, Cohen's kappa value, observed agreement, correlation analysis, and the area under the curve (AUC, ROC curve). Results 196 older adults participated. According to the FRIED-P, 19.5% of them were frail, 56.9% were pre-frail and 23.6% were non-frail. For slowness, the observed sensitivity was 47.0%, the specificity was 96.5% and the AUC was 0.717. For weakness, the sensitivity was 46.2%, the specificity was 83.7%, and the AUC was 0.649. The overall Spearman correlation between the FRIED-P and the FRIED-Q was r = 0.721 with an observed agreement of 76.6% (weighted linear kappa value = 0.663, quadratic kappa value = 0.738). Conclusions The concordance between the FRIED-P and FRIED-Q was substantial, characterized by a very high specificity, but a moderate sensitivity. This alternative operationalization of the Fried Phenotype-i.e., including six replacement questions instead of two performance-based tests-can be considered to apply as screening tool to screen physical frailty in large populations.
KW - Frailty
KW - Fried Phenotype
KW - Screening
KW - Performance-based test
KW - Self-report question
KW - PERFORMANCE-BASED TESTS
KW - FRAILTY SCREENING TOOL
KW - SELF-REPORT
KW - HEALTH
KW - AREA
U2 - 10.1007/s41999-020-00337-8
DO - 10.1007/s41999-020-00337-8
M3 - Article
C2 - 32500516
SN - 1878-7649
VL - 11
SP - 793
EP - 801
JO - European Geriatric Medicine
JF - European Geriatric Medicine
IS - 5
ER -