Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results

Ard van Veelen; Robin van Geel; Yvo de Beer; Anne-Marie Dingemans; Leo Stolk; Rob Ter Heine; Frank de Vries; Sander Croes

doi:10.1002/bmc.4771

Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results

Ard van Veelen, Robin van Geel, Yvo de Beer, Anne-Marie Dingemans, Leo Stolk, Rob Ter Heine, Frank de Vries, Sander Croes

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	e4771
Number of pages	9
Journal	Biomedical Chromatography
Volume	34
Issue number	4
Early online date	6 Dec 2019
DOIs	https://doi.org/10.1002/bmc.4771
Publication status	Published - Apr 2020

Keywords

AFATINIB
AZD9291
CANCER
CRIZOTINIB
EGFR INHIBITORS
KINASE INHIBITORS
MASS-SPECTROMETRIC ASSAY
PHARMACOKINETICS
QUANTIFICATION
analysis
osimertinib
room temperature
stability
validation

Access to Document

10.1002/bmc.4771

Cite this

@article{4b6dcdbf28d44d2688e61d2a5be5b78b,

title = "Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results",

keywords = "AFATINIB, AZD9291, CANCER, CRIZOTINIB, EGFR INHIBITORS, KINASE INHIBITORS, MASS-SPECTROMETRIC ASSAY, PHARMACOKINETICS, QUANTIFICATION, analysis, osimertinib, room temperature, stability, validation",

author = "{van Veelen}, Ard and {van Geel}, Robin and {de Beer}, Yvo and Anne-Marie Dingemans and Leo Stolk and {Ter Heine}, Rob and {de Vries}, Frank and Sander Croes",

year = "2020",

month = apr,

doi = "10.1002/bmc.4771",

language = "English",

volume = "34",

journal = "Biomedical Chromatography",

issn = "0269-3879",

publisher = "John Wiley & Sons",

number = "4",

}

Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results. / van Veelen, Ard; van Geel, Robin; de Beer, Yvo ; Dingemans, Anne-Marie; Stolk, Leo; Ter Heine, Rob; de Vries, Frank ; Croes, Sander.

In: Biomedical Chromatography, Vol. 34, No. 4, e4771, 04.2020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Validation of an analytical method using HPLC-MS/MS to quantify osimertinib in human plasma and supplementary stability results

AU - van Veelen, Ard

AU - van Geel, Robin

AU - de Beer, Yvo

AU - Dingemans, Anne-Marie

AU - Stolk, Leo

AU - Ter Heine, Rob

AU - de Vries, Frank

AU - Croes, Sander

PY - 2020/4

Y1 - 2020/4

KW - AFATINIB

KW - AZD9291

KW - CANCER

KW - CRIZOTINIB

KW - EGFR INHIBITORS

KW - KINASE INHIBITORS

KW - MASS-SPECTROMETRIC ASSAY

KW - PHARMACOKINETICS

KW - QUANTIFICATION

KW - analysis

KW - osimertinib

KW - room temperature

KW - stability

KW - validation

U2 - 10.1002/bmc.4771

DO - 10.1002/bmc.4771

M3 - Article

C2 - 31808583

VL - 34

JO - Biomedical Chromatography

JF - Biomedical Chromatography

SN - 0269-3879

IS - 4

M1 - e4771

ER -