Utilizing the Foreign Body Response to Grow Tissue Engineered Blood Vessels in Vivo

Wouter J. Geelhoed, Lorenzo Moroni, Joris I. Rotmans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Web of Science)

Abstract

It is well known that the number of patients requiring a vascular grafts for use as vessel replacement in cardiovascular diseases, or as vascular access site for hemodialysis is ever increasing. The development of tissue engineered blood vessels (TEBV's) is a promising method to meet this increasing demand vascular grafts, without having to rely on poorly performing synthetic options such as polytetrafluoroethylene (PTFE) or Dacron. The generation of in vivo TEBV's involves utilizing the host reaction to an implanted biomaterial for the generation of completely autologous tissues. Essentially this approach to the development of TEBV's makes use of the foreign body response to biomaterials for the construction of the entire vascular replacement tissue within the patient's own body. In this review we will discuss the method of developing in vivo TEBV's, and debate the approaches of several research groups that have implemented this method.

Original languageEnglish
Pages (from-to)167-179
Number of pages13
JournalJournal of Cardiovascular Translational Research
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Vascular tissue engineering
  • Tissue engineering
  • In vivo tissue engineering
  • Graft
  • Vascular graft
  • Vasculature
  • Vascular access
  • Animal models
  • Translational
  • Graft patency
  • Foreign body response
  • ACUTE INFLAMMATORY RESPONSES
  • BIOTUBE VASCULAR GRAFTS
  • GIANT-CELL FORMATION
  • EXTRACELLULAR-MATRIX
  • SPARKS-MANDRIL
  • COMPLEMENT ACTIVATION
  • MOLECULAR-BASIS
  • ELASTIC FIBER
  • FOLLOW-UP
  • BIOMATERIALS

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