Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy: a multicentre cross-sectional study

Lara Terra, Bernadette A. M. Heemskerk-Gerritsen, Maarten J. Beekman, Ellen Engelhardt, Marian J. E. Mourits, Helena C. van Doorn, Joanna A. de Hullu, Constantijne H. Mom, Brigitte F. M. Slangen, Katja N. Gaarenstroom, Marc van Beurden, Jeanine Roeters E. Van Lennep, Eleonora B. L. van Dorst, Lizet E. van Der Kolk, J. Margriet Collee, Marijke R. Wevers, Margreet G. . E. M. Ausems, Klaartje van Engelen, Irma van de Beek, Lieke P. V. BergerChristi J. van Asperen, Encarna Gomez B. Garcia, Angela H. E. M. Maas, Maartje J. Hooning, Anneke B. Steensma, Flora E. van Leeuwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later. Design: Cross-sectional study, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study. Methods: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders. Main outcome measures: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO. Results: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93–4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2–10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46). Conclusions: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalBjog-an International Journal of Obstetrics and Gynaecology
Issue number1
Early online date1 Jul 2023
Publication statusPublished - Jan 2024


  • BRCA pathogenic variant carriers
  • health-related quality of life
  • menopause
  • premenopausal RRSO
  • preventive bilateral salpingo-oophorectomy
  • stress incontinence
  • urge incontinence


Dive into the research topics of 'Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy: a multicentre cross-sectional study'. Together they form a unique fingerprint.

Cite this