TY - JOUR
T1 - Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy
T2 - a multicentre cross-sectional study
AU - Terra, Lara
AU - Heemskerk-Gerritsen, Bernadette A. M.
AU - Beekman, Maarten J.
AU - Engelhardt, Ellen
AU - Mourits, Marian J. E.
AU - van Doorn, Helena C.
AU - de Hullu, Joanna A.
AU - Mom, Constantijne H.
AU - Slangen, Brigitte F. M.
AU - Gaarenstroom, Katja N.
AU - van Beurden, Marc
AU - Van Lennep, Jeanine Roeters E.
AU - van Dorst, Eleonora B. L.
AU - van Der Kolk, Lizet E.
AU - Collee, J. Margriet
AU - Wevers, Marijke R.
AU - Ausems, Margreet G. . E. M.
AU - van Engelen, Klaartje
AU - van de Beek, Irma
AU - Berger, Lieke P. V.
AU - van Asperen, Christi J.
AU - Garcia, Encarna Gomez B.
AU - Maas, Angela H. E. M.
AU - Hooning, Maartje J.
AU - Steensma, Anneke B.
AU - van Leeuwen, Flora E.
PY - 2024/1
Y1 - 2024/1
N2 - Objective: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later. Design: Cross-sectional study, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study. Methods: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders. Main outcome measures: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO. Results: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93–4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2–10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46). Conclusions: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.
AB - Objective: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later. Design: Cross-sectional study, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study. Methods: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders. Main outcome measures: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO. Results: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93–4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2–10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46). Conclusions: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.
KW - BRCA pathogenic variant carriers
KW - health-related quality of life
KW - menopause
KW - premenopausal RRSO
KW - preventive bilateral salpingo-oophorectomy
KW - stress incontinence
KW - urge incontinence
KW - MENOPAUSAL TRANSITION
KW - IMPACT QUESTIONNAIRE
KW - WOMEN
KW - MANAGEMENT
KW - DISTRESS
U2 - 10.1111/1471-0528.17591
DO - 10.1111/1471-0528.17591
M3 - Article
C2 - 37394722
SN - 1470-0328
VL - 131
SP - 99
EP - 108
JO - Bjog-an International Journal of Obstetrics and Gynaecology
JF - Bjog-an International Journal of Obstetrics and Gynaecology
IS - 1
ER -