Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies

Dorien E.C.M. de Vocht; John John B. Schnog; Ingemar S. Merkies; Michael J. Samson

doi:10.1016/j.lana.2023.100584

Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies

Dorien E.C.M. de Vocht, John John B. Schnog, Ingemar S. Merkies, Michael J. Samson^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.

Original language	English
Article number	100584
Number of pages	10
Journal	Lancet Regional Health - Americas
Volume	25
Issue number	1
Early online date	1 Sept 2023
DOIs	https://doi.org/10.1016/j.lana.2023.100584
Publication status	Published - Sept 2023

Keywords

Brain metastases
Stereotactic radiotherapy
Whole brain radiotherapy

Access to Document

10.1016/j.lana.2023.100584Licence: CC BY-NC-ND

Cite this

@article{6f35ef6477ef4eab8c8dee0441509727,

title = "Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies",

abstract = "The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.",

keywords = "Brain metastases, Stereotactic radiotherapy, Whole brain radiotherapy",

author = "{de Vocht}, {Dorien E.C.M.} and Schnog, {John John B.} and Merkies, {Ingemar S.} and Samson, {Michael J.}",

note = "Funding Information: Funding information: The authors received no specific funding for this work. Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

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doi = "10.1016/j.lana.2023.100584",

language = "English",

volume = "25",

journal = "Lancet Regional Health - Americas",

issn = "2667-193X",

publisher = "The Lancet Publishing Group",

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Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies. / de Vocht, Dorien E.C.M.; Schnog, John John B.; Merkies, Ingemar S. et al.
In: Lancet Regional Health - Americas, Vol. 25, No. 1, 100584, 09.2023.

Research output: Contribution to journal › (Systematic) Review article › peer-review

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AU - de Vocht, Dorien E.C.M.

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AU - Samson, Michael J.

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AB - The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.

KW - Brain metastases

KW - Stereotactic radiotherapy

KW - Whole brain radiotherapy

U2 - 10.1016/j.lana.2023.100584

DO - 10.1016/j.lana.2023.100584

M3 - (Systematic) Review article

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VL - 25

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