TY - JOUR
T1 - Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies
AU - de Vocht, Dorien E.C.M.
AU - Schnog, John John B.
AU - Merkies, Ingemar S.
AU - Samson, Michael J.
N1 - Funding Information:
Funding information: The authors received no specific funding for this work.
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/9
Y1 - 2023/9
N2 - The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.
AB - The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.
KW - Brain metastases
KW - Stereotactic radiotherapy
KW - Whole brain radiotherapy
U2 - 10.1016/j.lana.2023.100584
DO - 10.1016/j.lana.2023.100584
M3 - (Systematic) Review article
SN - 2667-193X
VL - 25
JO - Lancet Regional Health - Americas
JF - Lancet Regional Health - Americas
IS - 1
M1 - 100584
ER -