Abstract
Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways, focussing on hyperglycaemia, (micro)vascular dysfunction, and low-grade inflammation. Although there is accumulating evidence that these pathways are involved in the link between type 2 diabetes and depression, direct evidence of their temporal associations is lacking because of a paucity of longitudinal studies that focus on the pathobiology of both type 2 diabetes and depression.
Original language | English |
---|---|
Article number | 1283 |
Journal | F1000Research |
Volume | 7 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- (micro-)vascular dysfunction
- Depression
- Hyperglycaemia
- Low-grade inflammation
- Type 2 diabetes