Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Jason Y Y Wong; Han Zhang; Chao A Hsiung; Kouya Shiraishi; Kai Yu; Keitaro Matsuo; Maria Pik Wong; Yun-Chul Hong; Jiucun Wang; Wei Jie Seow; Zhaoming Wang; Minsun Song; Hee Nam Kim; I-Shou Chang; Nilanjan Chatterjee; Wei Hu; Chen Wu; Tetsuya Mitsudomi; Wei Zheng; Jin Hee Kim; Adeline Seow; Neil E Caporaso; Min-Ho Shin; Lap Ping Chung; She-Juan An; Ping Wang; Yang Yang; Hong Zheng; Yasushi Yatabe; Xu-Chao Zhang; Young Tae Kim; Qiuyin Cai; Zhihua Yin; Young-Chul Kim; Bryan A Bassig; Jiang Chang; James Chung Man Ho; Bu-Tian Ji; Yataro Daigo; Hidemi Ito; Yukihide Momozawa; Kyota Ashikawa; Yoichiro Kamatani; Takayuki Honda; H Dean Hosgood; Hiromi Sakamoto; Hideo Kunitoh; Koji Tsuta; Shun-Ichi Watanabe; Michiaki Kubo; Yohei Miyagi; Haruhiko Nakayama; Shingo Matsumoto; Masahiro Tsuboi; Koichi Goto; Jianxin Shi; Lei Song; Xing Hua; Atsushi Takahashi; Akiteru Goto; Yoshihiro Minamiya; Kimihiro Shimizu; Kazumi Tanaka; Fusheng Wei; Fumihiko Matsuda; Jian Su; Yeul Hong Kim; In-Jae Oh; Fengju Song; Wu-Chou Su; Yu-Min Chen; Gee-Chen Chang; Kuan-Yu Chen; Ming-Shyan Huang; Li-Hsin Chien; Yong-Bing Xiang; Jae Yong Park; Sun-Seog Kweon; Chien-Jen Chen; Kyoung-Mu Lee; Batel Blechter; Haixin Li; Yu-Tang Gao; Biyun Qian; Daru Lu; Jianjun Liu; Hyo-Sung Jeon; Chin-Fu Hsiao; Jae Sook Sung; Ying-Huang Tsai; Yoo Jin Jung; Huan Guo; Zhibin Hu; Wen-Chang Wang; Charles C Chung; Laurie Burdett; Meredith Yeager; Amy Hutchinson; Sonja I Berndt; Wei Wu; Herbert Pang; Yuqing Li; Jin Eun Choi; Kyong Hwa Park; Sook Whan Sung; Li Liu; C H Kang; Meng Zhu; Chung-Hsing Chen; Tsung-Ying Yang; Jun Xu; Peng Guan; Wen Tan; Chih-Liang Wang; Michael Hsin; Ko-Yung Sit; James Ho; Ying Chen; Yi Young Choi; Jen-Yu Hung; Jun Suk Kim; Ho Il Yoon; Chien-Chung Lin; In Kyu Park; Ping Xu; Yuzhuo Wang; Qincheng He; Reury-Perng Perng; Chih-Yi Chen; Roel Vermeulen; Junjie Wu; Wei-Yen Lim; Kun-Chieh Chen; Yao-Jen Li; Jihua Li; Hongyan Chen; Chong-Jen Yu; Li Jin; Tzu-Yu Chen; Shih-Sheng Jiang; Jie Liu; Taiki Yamaji; Belynda Hicks; Kathleen Wyatt; Shengchao A Li; Juncheng Dai; Hongxia Ma; Guangfu Jin; Bao Song; Zhehai Wang; Sensen Cheng; Xuelian Li; Yangwu Ren; Ping Cui; Motoki Iwasaki; Taichi Shimazu; Shoichiro Tsugane; Junjie Zhu; Kaiyun Yang; Gening Jiang; Ke Fei; Guoping Wu; Hsien-Chin Lin; Hui-Ling Chen; Yao-Huei Fang; Fang-Yu Tsai; Wan-Shan Hsieh; Jinming Yu; Victoria L Stevens; Ite A Laird-Offringa; Crystal N Marconett; Linda Rieswijk; Ann Chao; Pan-Chyr Yang; Xiao-Ou Shu; Tangchun Wu; Y L Wu; Dongxin Lin; Kexin Chen; Baosen Zhou; Yun-Chao Huang; Takashi Kohno; Hongbing Shen; Stephen J Chanock; Nathaniel Rothman; Qing Lan; Linda Rieswijk

doi:10.1016/j.ygeno.2019.07.008

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Jason Y Y Wong^*, Han Zhang, Chao A Hsiung, Kouya Shiraishi, Kai Yu, Keitaro Matsuo, Maria Pik Wong, Yun-Chul Hong, Jiucun Wang, Wei Jie Seow, Zhaoming Wang, Minsun Song, Hee Nam Kim, I-Shou Chang, Nilanjan Chatterjee, Wei Hu, Chen Wu, Tetsuya Mitsudomi, Wei Zheng, Jin Hee KimAdeline Seow, Neil E Caporaso, Min-Ho Shin, Lap Ping Chung, She-Juan An, Ping Wang, Yang Yang, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Qiuyin Cai, Zhihua Yin, Young-Chul Kim, Bryan A Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Yataro Daigo, Hidemi Ito, Yukihide Momozawa, Kyota Ashikawa, Yoichiro Kamatani, Takayuki Honda, H Dean Hosgood, Hiromi Sakamoto, Hideo Kunitoh, Koji Tsuta, Shun-Ichi Watanabe, Michiaki Kubo, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Jianxin Shi, Lei Song, Xing Hua, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Fusheng Wei, Fumihiko Matsuda, Jian Su, Yeul Hong Kim, In-Jae Oh, Fengju Song, Wu-Chou Su, Yu-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Li-Hsin Chien, Yong-Bing Xiang, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Kyoung-Mu Lee, Batel Blechter, Haixin Li, Yu-Tang Gao, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Wen-Chang Wang, Charles C Chung, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I Berndt, Wei Wu, Herbert Pang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, C H Kang, Meng Zhu, Chung-Hsing Chen, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Michael Hsin, Ko-Yung Sit, James Ho, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho Il Yoon, Chien-Chung Lin, In Kyu Park, Ping Xu, Yuzhuo Wang, Qincheng He, Reury-Perng Perng, Chih-Yi Chen, Roel Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, Yao-Jen Li, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Tzu-Yu Chen, Shih-Sheng Jiang, Jie Liu, Taiki Yamaji, Belynda Hicks, Kathleen Wyatt, Shengchao A Li, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ping Cui, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Kaiyun Yang, Gening Jiang, Ke Fei, Guoping Wu, Hsien-Chin Lin, Hui-Ling Chen, Yao-Huei Fang, Fang-Yu Tsai, Wan-Shan Hsieh, Jinming Yu, Victoria L Stevens, Ite A Laird-Offringa, Crystal N Marconett, Linda Rieswijk, Ann Chao, Pan-Chyr Yang, Xiao-Ou Shu, Tangchun Wu, Y L Wu, Dongxin Lin, Kexin Chen, Baosen Zhou, Yun-Chao Huang, Takashi Kohno, Hongbing Shen, Stephen J Chanock, Nathaniel Rothman, Qing Lan, Linda Rieswijk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

Original language	English
Pages (from-to)	1223-1232
Number of pages	10
Journal	Genomics
Volume	112
Issue number	2
Early online date	12 Jul 2019
DOIs	https://doi.org/10.1016/j.ygeno.2019.07.008
Publication status	Published - Mar 2020

Keywords

APOPTOSIS
CANCER SUSCEPTIBILITY LOCI
DISEASE
Lung adenocarcinoma
Lung cancer
MEN
Mendelian randomization
PULMONARY TUBERCULOSIS
Pathway analysis
RISK
SMOKERS
Tuberculosis
VARIANTS

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10.1016/j.ygeno.2019.07.008

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Cite this

Wong, J. Y. Y., Zhang, H., Hsiung, C. A., Shiraishi, K., Yu, K., Matsuo, K., Wong, M. P., Hong, Y-C., Wang, J., Seow, W. J., Wang, Z., Song, M., Kim, H. N., Chang, I-S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., ... Rieswijk, L. (2020). Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women. Genomics, 112(2), 1223-1232. https://doi.org/10.1016/j.ygeno.2019.07.008

@article{8824888145304cd8a490e83b35c99cbc,

title = "Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women",

abstract = "We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.",

keywords = "APOPTOSIS, CANCER SUSCEPTIBILITY LOCI, DISEASE, Lung adenocarcinoma, Lung cancer, MEN, Mendelian randomization, PULMONARY TUBERCULOSIS, Pathway analysis, RISK, SMOKERS, Tuberculosis, VARIANTS",

author = "Wong, {Jason Y Y} and Han Zhang and Hsiung, {Chao A} and Kouya Shiraishi and Kai Yu and Keitaro Matsuo and Wong, {Maria Pik} and Yun-Chul Hong and Jiucun Wang and Seow, {Wei Jie} and Zhaoming Wang and Minsun Song and Kim, {Hee Nam} and I-Shou Chang and Nilanjan Chatterjee and Wei Hu and Chen Wu and Tetsuya Mitsudomi and Wei Zheng and Kim, {Jin Hee} and Adeline Seow and Caporaso, {Neil E} and Min-Ho Shin and Chung, {Lap Ping} and She-Juan An and Ping Wang and Yang Yang and Hong Zheng and Yasushi Yatabe and Xu-Chao Zhang and Kim, {Young Tae} and Qiuyin Cai and Zhihua Yin and Young-Chul Kim and Bassig, {Bryan A} and Jiang Chang and Ho, {James Chung Man} and Bu-Tian Ji and Yataro Daigo and Hidemi Ito and Yukihide Momozawa and Kyota Ashikawa and Yoichiro Kamatani and Takayuki Honda and Hosgood, {H Dean} and Hiromi Sakamoto and Hideo Kunitoh and Koji Tsuta and Shun-Ichi Watanabe and Michiaki Kubo and Yohei Miyagi and Haruhiko Nakayama and Shingo Matsumoto and Masahiro Tsuboi and Koichi Goto and Jianxin Shi and Lei Song and Xing Hua and Atsushi Takahashi and Akiteru Goto and Yoshihiro Minamiya and Kimihiro Shimizu and Kazumi Tanaka and Fusheng Wei and Fumihiko Matsuda and Jian Su and Kim, {Yeul Hong} and In-Jae Oh and Fengju Song and Wu-Chou Su and Yu-Min Chen and Gee-Chen Chang and Kuan-Yu Chen and Ming-Shyan Huang and Li-Hsin Chien and Yong-Bing Xiang and Park, {Jae Yong} and Sun-Seog Kweon and Chien-Jen Chen and Kyoung-Mu Lee and Batel Blechter and Haixin Li and Yu-Tang Gao and Biyun Qian and Daru Lu and Jianjun Liu and Hyo-Sung Jeon and Chin-Fu Hsiao and Sung, {Jae Sook} and Ying-Huang Tsai and Jung, {Yoo Jin} and Huan Guo and Zhibin Hu and Wen-Chang Wang and Chung, {Charles C} and Laurie Burdett and Meredith Yeager and Amy Hutchinson and Berndt, {Sonja I} and Wei Wu and Herbert Pang and Yuqing Li and Choi, {Jin Eun} and Park, {Kyong Hwa} and Sung, {Sook Whan} and Li Liu and Kang, {C H} and Meng Zhu and Chung-Hsing Chen and Tsung-Ying Yang and Jun Xu and Peng Guan and Wen Tan and Chih-Liang Wang and Michael Hsin and Ko-Yung Sit and James Ho and Ying Chen and Choi, {Yi Young} and Jen-Yu Hung and Kim, {Jun Suk} and Yoon, {Ho Il} and Chien-Chung Lin and Park, {In Kyu} and Ping Xu and Yuzhuo Wang and Qincheng He and Reury-Perng Perng and Chih-Yi Chen and Roel Vermeulen and Junjie Wu and Wei-Yen Lim and Kun-Chieh Chen and Yao-Jen Li and Jihua Li and Hongyan Chen and Chong-Jen Yu and Li Jin and Tzu-Yu Chen and Shih-Sheng Jiang and Jie Liu and Taiki Yamaji and Belynda Hicks and Kathleen Wyatt and Li, {Shengchao A} and Juncheng Dai and Hongxia Ma and Guangfu Jin and Bao Song and Zhehai Wang and Sensen Cheng and Xuelian Li and Yangwu Ren and Ping Cui and Motoki Iwasaki and Taichi Shimazu and Shoichiro Tsugane and Junjie Zhu and Kaiyun Yang and Gening Jiang and Ke Fei and Guoping Wu and Hsien-Chin Lin and Hui-Ling Chen and Yao-Huei Fang and Fang-Yu Tsai and Wan-Shan Hsieh and Jinming Yu and Stevens, {Victoria L} and Laird-Offringa, {Ite A} and Marconett, {Crystal N} and Linda Rieswijk and Ann Chao and Pan-Chyr Yang and Xiao-Ou Shu and Tangchun Wu and Wu, {Y L} and Dongxin Lin and Kexin Chen and Baosen Zhou and Yun-Chao Huang and Takashi Kohno and Hongbing Shen and Chanock, {Stephen J} and Nathaniel Rothman and Qing Lan and Linda Rieswijk",

note = "Copyright {\textcopyright} 2018. Published by Elsevier Inc.",

year = "2020",

month = mar,

doi = "10.1016/j.ygeno.2019.07.008",

language = "English",

volume = "112",

pages = "1223--1232",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

Wong, JYY, Zhang, H, Hsiung, CA, Shiraishi, K, Yu, K, Matsuo, K, Wong, MP, Hong, Y-C, Wang, J, Seow, WJ, Wang, Z, Song, M, Kim, HN, Chang, I-S, Chatterjee, N, Hu, W, Wu, C, Mitsudomi, T, Zheng, W, Kim, JH, Seow, A, Caporaso, NE, Shin, M-H, Chung, LP, An, S-J, Wang, P, Yang, Y, Zheng, H, Yatabe, Y, Zhang, X-C, Kim, YT, Cai, Q, Yin, Z, Kim, Y-C, Bassig, BA, Chang, J, Ho, JCM, Ji, B-T, Daigo, Y, Ito, H, Momozawa, Y, Ashikawa, K, Kamatani, Y, Honda, T, Hosgood, HD, Sakamoto, H, Kunitoh, H, Tsuta, K, Watanabe, S-I, Kubo, M, Miyagi, Y, Nakayama, H, Matsumoto, S, Tsuboi, M, Goto, K, Shi, J, Song, L, Hua, X, Takahashi, A, Goto, A, Minamiya, Y, Shimizu, K, Tanaka, K, Wei, F, Matsuda, F, Su, J, Kim, YH, Oh, I-J, Song, F, Su, W-C, Chen, Y-M, Chang, G-C, Chen, K-Y, Huang, M-S, Chien, L-H, Xiang, Y-B, Park, JY, Kweon, S-S, Chen, C-J, Lee, K-M, Blechter, B, Li, H, Gao, Y-T, Qian, B, Lu, D, Liu, J, Jeon, H-S, Hsiao, C-F, Sung, JS, Tsai, Y-H, Jung, YJ, Guo, H, Hu, Z, Wang, W-C, Chung, CC, Burdett, L, Yeager, M, Hutchinson, A, Berndt, SI, Wu, W, Pang, H, Li, Y, Choi, JE, Park, KH, Sung, SW, Liu, L, Kang, CH, Zhu, M, Chen, C-H, Yang, T-Y, Xu, J, Guan, P, Tan, W, Wang, C-L, Hsin, M, Sit, K-Y, Ho, J, Chen, Y, Choi, YY, Hung, J-Y, Kim, JS, Yoon, HI, Lin, C-C, Park, IK, Xu, P, Wang, Y, He, Q, Perng, R-P, Chen, C-Y, Vermeulen, R, Wu, J, Lim, W-Y, Chen, K-C, Li, Y-J, Li, J, Chen, H, Yu, C-J, Jin, L, Chen, T-Y, Jiang, S-S, Liu, J, Yamaji, T, Hicks, B, Wyatt, K, Li, SA, Dai, J, Ma, H, Jin, G, Song, B, Wang, Z, Cheng, S, Li, X, Ren, Y, Cui, P, Iwasaki, M, Shimazu, T, Tsugane, S, Zhu, J, Yang, K, Jiang, G, Fei, K, Wu, G, Lin, H-C, Chen, H-L, Fang, Y-H, Tsai, F-Y, Hsieh, W-S, Yu, J, Stevens, VL, Laird-Offringa, IA, Marconett, CN, Rieswijk, L, Chao, A, Yang, P-C, Shu, X-O, Wu, T, Wu, YL, Lin, D, Chen, K, Zhou, B, Huang, Y-C, Kohno, T, Shen, H, Chanock, SJ, Rothman, N, Lan, Q & Rieswijk, L 2020, 'Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women', Genomics, vol. 112, no. 2, pp. 1223-1232. https://doi.org/10.1016/j.ygeno.2019.07.008

TY - JOUR

T1 - Tuberculosis infection and lung adenocarcinoma

T2 - Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

AU - Wong, Jason Y Y

AU - Zhang, Han

AU - Hsiung, Chao A

AU - Shiraishi, Kouya

AU - Yu, Kai

AU - Matsuo, Keitaro

AU - Wong, Maria Pik

AU - Hong, Yun-Chul

AU - Wang, Jiucun

AU - Seow, Wei Jie

AU - Wang, Zhaoming

AU - Song, Minsun

AU - Kim, Hee Nam

AU - Chang, I-Shou

AU - Chatterjee, Nilanjan

AU - Hu, Wei

AU - Wu, Chen

AU - Mitsudomi, Tetsuya

AU - Zheng, Wei

AU - Kim, Jin Hee

AU - Seow, Adeline

AU - Caporaso, Neil E

AU - Shin, Min-Ho

AU - Chung, Lap Ping

AU - An, She-Juan

AU - Wang, Ping

AU - Yang, Yang

AU - Zheng, Hong

AU - Yatabe, Yasushi

AU - Zhang, Xu-Chao

AU - Kim, Young Tae

AU - Cai, Qiuyin

AU - Yin, Zhihua

AU - Kim, Young-Chul

AU - Bassig, Bryan A

AU - Chang, Jiang

AU - Ho, James Chung Man

AU - Ji, Bu-Tian

AU - Daigo, Yataro

AU - Ito, Hidemi

AU - Momozawa, Yukihide

AU - Ashikawa, Kyota

AU - Kamatani, Yoichiro

AU - Honda, Takayuki

AU - Hosgood, H Dean

AU - Sakamoto, Hiromi

AU - Kunitoh, Hideo

AU - Tsuta, Koji

AU - Watanabe, Shun-Ichi

AU - Kubo, Michiaki

AU - Miyagi, Yohei

AU - Nakayama, Haruhiko

AU - Matsumoto, Shingo

AU - Tsuboi, Masahiro

AU - Goto, Koichi

AU - Shi, Jianxin

AU - Song, Lei

AU - Hua, Xing

AU - Takahashi, Atsushi

AU - Goto, Akiteru

AU - Minamiya, Yoshihiro

AU - Shimizu, Kimihiro

AU - Tanaka, Kazumi

AU - Wei, Fusheng

AU - Matsuda, Fumihiko

AU - Su, Jian

AU - Kim, Yeul Hong

AU - Oh, In-Jae

AU - Song, Fengju

AU - Su, Wu-Chou

AU - Chen, Yu-Min

AU - Chang, Gee-Chen

AU - Chen, Kuan-Yu

AU - Huang, Ming-Shyan

AU - Chien, Li-Hsin

AU - Xiang, Yong-Bing

AU - Park, Jae Yong

AU - Kweon, Sun-Seog

AU - Chen, Chien-Jen

AU - Lee, Kyoung-Mu

AU - Blechter, Batel

AU - Li, Haixin

AU - Gao, Yu-Tang

AU - Qian, Biyun

AU - Lu, Daru

AU - Liu, Jianjun

AU - Jeon, Hyo-Sung

AU - Hsiao, Chin-Fu

AU - Sung, Jae Sook

AU - Tsai, Ying-Huang

AU - Jung, Yoo Jin

AU - Guo, Huan

AU - Hu, Zhibin

AU - Wang, Wen-Chang

AU - Chung, Charles C

AU - Burdett, Laurie

AU - Yeager, Meredith

AU - Hutchinson, Amy

AU - Berndt, Sonja I

AU - Wu, Wei

AU - Pang, Herbert

AU - Li, Yuqing

AU - Choi, Jin Eun

AU - Park, Kyong Hwa

AU - Sung, Sook Whan

AU - Liu, Li

AU - Kang, C H

AU - Zhu, Meng

AU - Chen, Chung-Hsing

AU - Yang, Tsung-Ying

AU - Xu, Jun

AU - Guan, Peng

AU - Tan, Wen

AU - Wang, Chih-Liang

AU - Hsin, Michael

AU - Sit, Ko-Yung

AU - Ho, James

AU - Chen, Ying

AU - Choi, Yi Young

AU - Hung, Jen-Yu

AU - Kim, Jun Suk

AU - Yoon, Ho Il

AU - Lin, Chien-Chung

AU - Park, In Kyu

AU - Xu, Ping

AU - Wang, Yuzhuo

AU - He, Qincheng

AU - Perng, Reury-Perng

AU - Chen, Chih-Yi

AU - Vermeulen, Roel

AU - Wu, Junjie

AU - Lim, Wei-Yen

AU - Chen, Kun-Chieh

AU - Li, Yao-Jen

AU - Li, Jihua

AU - Chen, Hongyan

AU - Yu, Chong-Jen

AU - Jin, Li

AU - Chen, Tzu-Yu

AU - Jiang, Shih-Sheng

AU - Liu, Jie

AU - Yamaji, Taiki

AU - Hicks, Belynda

AU - Wyatt, Kathleen

AU - Li, Shengchao A

AU - Dai, Juncheng

AU - Ma, Hongxia

AU - Jin, Guangfu

AU - Song, Bao

AU - Wang, Zhehai

AU - Cheng, Sensen

AU - Li, Xuelian

AU - Ren, Yangwu

AU - Cui, Ping

AU - Iwasaki, Motoki

AU - Shimazu, Taichi

AU - Tsugane, Shoichiro

AU - Zhu, Junjie

AU - Yang, Kaiyun

AU - Jiang, Gening

AU - Fei, Ke

AU - Wu, Guoping

AU - Lin, Hsien-Chin

AU - Chen, Hui-Ling

AU - Fang, Yao-Huei

AU - Tsai, Fang-Yu

AU - Hsieh, Wan-Shan

AU - Yu, Jinming

AU - Stevens, Victoria L

AU - Laird-Offringa, Ite A

AU - Marconett, Crystal N

AU - Rieswijk, Linda

AU - Chao, Ann

AU - Yang, Pan-Chyr

AU - Shu, Xiao-Ou

AU - Wu, Tangchun

AU - Wu, Y L

AU - Lin, Dongxin

AU - Chen, Kexin

AU - Zhou, Baosen

AU - Huang, Yun-Chao

AU - Kohno, Takashi

AU - Shen, Hongbing

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Lan, Qing

AU - Rieswijk, Linda

PY - 2020/3

Y1 - 2020/3

N2 - We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

AB - We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

KW - APOPTOSIS

KW - CANCER SUSCEPTIBILITY LOCI

KW - DISEASE

KW - Lung adenocarcinoma

KW - Lung cancer

KW - MEN

KW - Mendelian randomization

KW - PULMONARY TUBERCULOSIS

KW - Pathway analysis

KW - RISK

KW - SMOKERS

KW - Tuberculosis

KW - VARIANTS

U2 - 10.1016/j.ygeno.2019.07.008

DO - 10.1016/j.ygeno.2019.07.008

M3 - Article

C2 - 31306748

SN - 0888-7543

VL - 112

SP - 1223

EP - 1232

JO - Genomics

JF - Genomics

IS - 2

ER -