tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function

Eleni Liapi; Marc van Bilsen; Robin Verjans; Blanche Schroen

doi:10.1016/j.bbamcr.2019.03.012

tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function

Eleni Liapi, Marc van Bilsen, Robin Verjans, Blanche Schroen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.

Original language	English
Article number	118465
Number of pages	9
Journal	Biochimica et Biophysica Acta-Molecular Cell Research
Volume	1867
Issue number	3
DOIs	https://doi.org/10.1016/j.bbamcr.2019.03.012
Publication status	Published - Mar 2020
Event	9th Ascona International Workshop on Cardiomyocyte Biology - New Pathways of Differentiation and Regeneration - Ascona, Switzerland Duration: 1 Jan 2018 → …

Keywords

tRNA
Heart
Cardiomyocyte
Skeletal muscle
tRNA-derived small RNA
tRNA synthetases
POLYMERASE-III TRANSCRIPTION
PHENYLALANINE TRANSFER-RNA
CELL-CYCLE
NONCODING RNAS
STRESS
METHYLATION
GENES
SYNTHETASE
DATABASE
PATHOPHYSIOLOGY

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title = "tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function",

abstract = "Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.",

keywords = "tRNA, Heart, Cardiomyocyte, Skeletal muscle, tRNA-derived small RNA, tRNA synthetases, POLYMERASE-III TRANSCRIPTION, PHENYLALANINE TRANSFER-RNA, CELL-CYCLE, NONCODING RNAS, STRESS, METHYLATION, GENES, SYNTHETASE, DATABASE, PATHOPHYSIOLOGY",

author = "Eleni Liapi and {van Bilsen}, Marc and Robin Verjans and Blanche Schroen",

note = "Funding Information: This work was supported by grants from the Netherlands Heart Foundation (Dekker 2014T105 and CVON-SHE-PREDICTS-HF to BS), Netherlands Organisation for Scientific Research (NWO vidi 917.14.363 to BS), Health Foundation Limburg (to BS), an ERA-CVD Joint International Call grant (Netherlands Heart Foundation and NWO-ZonMw Grant no. 2016T091 to MvB). Funding Information: This work was supported by grants from the Netherlands Heart Foundation (Dekker 2014T105 and CVON-SHE-PREDICTS-HF to BS), Netherlands Organisation for Scientific Research (NWO vidi 917.14.363 to BS), Health Foundation Limburg (to BS), an ERA-CVD Joint International Call grant (Netherlands Heart Foundation and NWO-ZonMw Grant no. 2016T091 to MvB). Publisher Copyright: {\textcopyright} 2019 The Authors; 9th Ascona International Workshop on Cardiomyocyte Biology - New Pathways of Differentiation and Regeneration ; Conference date: 01-01-2018",

year = "2020",

month = mar,

doi = "10.1016/j.bbamcr.2019.03.012",

language = "English",

volume = "1867",

journal = "Biochimica et Biophysica Acta-Molecular Cell Research",

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T1 - tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function

AU - Liapi, Eleni

AU - van Bilsen, Marc

AU - Verjans, Robin

AU - Schroen, Blanche

N1 - Funding Information: This work was supported by grants from the Netherlands Heart Foundation (Dekker 2014T105 and CVON-SHE-PREDICTS-HF to BS), Netherlands Organisation for Scientific Research (NWO vidi 917.14.363 to BS), Health Foundation Limburg (to BS), an ERA-CVD Joint International Call grant (Netherlands Heart Foundation and NWO-ZonMw Grant no. 2016T091 to MvB). Funding Information: This work was supported by grants from the Netherlands Heart Foundation (Dekker 2014T105 and CVON-SHE-PREDICTS-HF to BS), Netherlands Organisation for Scientific Research (NWO vidi 917.14.363 to BS), Health Foundation Limburg (to BS), an ERA-CVD Joint International Call grant (Netherlands Heart Foundation and NWO-ZonMw Grant no. 2016T091 to MvB). Publisher Copyright: © 2019 The Authors

PY - 2020/3

Y1 - 2020/3

N2 - Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.

AB - Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.

KW - tRNA

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KW - Cardiomyocyte

KW - Skeletal muscle

KW - tRNA-derived small RNA

KW - tRNA synthetases

KW - POLYMERASE-III TRANSCRIPTION

KW - PHENYLALANINE TRANSFER-RNA

KW - CELL-CYCLE

KW - NONCODING RNAS

KW - STRESS

KW - METHYLATION

KW - GENES

KW - SYNTHETASE

KW - DATABASE

KW - PATHOPHYSIOLOGY

U2 - 10.1016/j.bbamcr.2019.03.012

DO - 10.1016/j.bbamcr.2019.03.012

M3 - Article

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VL - 1867

JO - Biochimica et Biophysica Acta-Molecular Cell Research

JF - Biochimica et Biophysica Acta-Molecular Cell Research

IS - 3

M1 - 118465

T2 - 9th Ascona International Workshop on Cardiomyocyte Biology - New Pathways of Differentiation and Regeneration

Y2 - 1 January 2018

ER -

tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function

Abstract

Keywords

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