tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function

Eleni Liapi, Marc van Bilsen, Robin Verjans, Blanche Schroen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)

Abstract

Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.

Original languageEnglish
Article number118465
Number of pages9
JournalBiochimica et Biophysica Acta-Molecular Cell Research
Volume1867
Issue number3
DOIs
Publication statusPublished - Mar 2020
Event9th Ascona International Workshop on Cardiomyocyte Biology - New Pathways of Differentiation and Regeneration - Ascona, Switzerland
Duration: 1 Jan 2018 → …

Keywords

  • tRNA
  • Heart
  • Cardiomyocyte
  • Skeletal muscle
  • tRNA-derived small RNA
  • tRNA synthetases
  • POLYMERASE-III TRANSCRIPTION
  • PHENYLALANINE TRANSFER-RNA
  • CELL-CYCLE
  • NONCODING RNAS
  • STRESS
  • METHYLATION
  • GENES
  • SYNTHETASE
  • DATABASE
  • PATHOPHYSIOLOGY

Cite this