Triple Red Blood Cell Alloantibody Formation After Bone-Allograft Transplantation

L. Prinzen*, H. M. Staal, S. J. M. Rouwette, E. A. M. Beckers, R. H. M. ten Broeke, L. W. van Rhijn, Y. M. C. Henskens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)


In this case report, we provide evidence for the possibility of red blood cell alloimmunization after bone-allograft transplantation. Here, we present a 13-year-old boy who received a bone allograft due to impending hip-luxation. Five months later he was shown to have developed three different alloantibodies: anti-D, anti-C and anti-E, which were induced by the bone allograft. Red blood cell alloimmunization is a possible adverse event when a patient is exposed to allogenic red blood cells. These antibodies may cause transfusion reactions when incompatible blood is administered. More importantly, these antibodies may cause severe, or even fatal, hemolytic disease of the fetus or newborn, stretching the importance of preventing antibody formation, especially in young women. This case demonstrates the importance of selecting rhesus phenotype compatible bone allografts.
Original languageEnglish
Pages (from-to)229-231
JournalAmerican Journal of Transplantation
Issue number1
Publication statusPublished - Jan 2013


  • Alloimmunization
  • bone allograft
  • red blood cell immunization
  • rhesus incompatability

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