TY - JOUR
T1 - Triple Red Blood Cell Alloantibody Formation After Bone-Allograft Transplantation
AU - Prinzen, L.
AU - Staal, H. M.
AU - Rouwette, S. J. M.
AU - Beckers, E. A. M.
AU - ten Broeke, R. H. M.
AU - van Rhijn, L. W.
AU - Henskens, Y. M. C.
PY - 2013/1
Y1 - 2013/1
N2 - In this case report, we provide evidence for the possibility of red blood cell alloimmunization after bone-allograft transplantation. Here, we present a 13-year-old boy who received a bone allograft due to impending hip-luxation. Five months later he was shown to have developed three different alloantibodies: anti-D, anti-C and anti-E, which were induced by the bone allograft. Red blood cell alloimmunization is a possible adverse event when a patient is exposed to allogenic red blood cells. These antibodies may cause transfusion reactions when incompatible blood is administered. More importantly, these antibodies may cause severe, or even fatal, hemolytic disease of the fetus or newborn, stretching the importance of preventing antibody formation, especially in young women. This case demonstrates the importance of selecting rhesus phenotype compatible bone allografts.
AB - In this case report, we provide evidence for the possibility of red blood cell alloimmunization after bone-allograft transplantation. Here, we present a 13-year-old boy who received a bone allograft due to impending hip-luxation. Five months later he was shown to have developed three different alloantibodies: anti-D, anti-C and anti-E, which were induced by the bone allograft. Red blood cell alloimmunization is a possible adverse event when a patient is exposed to allogenic red blood cells. These antibodies may cause transfusion reactions when incompatible blood is administered. More importantly, these antibodies may cause severe, or even fatal, hemolytic disease of the fetus or newborn, stretching the importance of preventing antibody formation, especially in young women. This case demonstrates the importance of selecting rhesus phenotype compatible bone allografts.
KW - Alloimmunization
KW - bone allograft
KW - red blood cell immunization
KW - rhesus incompatability
U2 - 10.1111/j.1600-6143.2012.04300.x
DO - 10.1111/j.1600-6143.2012.04300.x
M3 - Article
SN - 1600-6135
VL - 13
SP - 229
EP - 231
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 1
ER -