Treatment of cystoid macular edema after cataract surgery

Laura H P Wielders; Jan S A G Schouten; Merel R Aberle; Verena A Lambermont; Frank J H M van den Biggelaar; Bjorn Winkens; Rob W P Simons; Rudy M M A Nuijts

doi:10.1016/j.jcrs.2016.06.041

Treatment of cystoid macular edema after cataract surgery

Laura H P Wielders^*, Jan S A G Schouten, Merel R Aberle, Verena A Lambermont, Frank J H M van den Biggelaar, Bjorn Winkens, Rob W P Simons, Rudy M M A Nuijts

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present. Ten RCTs were included in the systematic review. Five trials included at least 30 participants. Three RCTs showed a greater visual acuity improvement in patients treated with topical nonsteroidal antiinflammatory drugs (NSAIDs) than with a placebo. Other studies comparing the efficacy of topical NSAIDs, topical corticosteroids, sub-Tenon corticosteroids, oral NSAIDs, and oral acetazolamide did not report significant differences between treatment groups. Therefore, large RCTs are needed to provide evidence-based recommendations for the optimum treatment of CME after cataract surgery.

Original language	English
Pages (from-to)	276-284
Number of pages	9
Journal	Journal of Cataract and Refractive Surgery
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.jcrs.2016.06.041
Publication status	Published - Feb 2017

Keywords

Journal Article
Review

Access to Document

10.1016/j.jcrs.2016.06.041

Cite this

@article{f33ad52d62d74ea284ce57ca80d26c3e,

title = "Treatment of cystoid macular edema after cataract surgery",

abstract = "The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present. Ten RCTs were included in the systematic review. Five trials included at least 30 participants. Three RCTs showed a greater visual acuity improvement in patients treated with topical nonsteroidal antiinflammatory drugs (NSAIDs) than with a placebo. Other studies comparing the efficacy of topical NSAIDs, topical corticosteroids, sub-Tenon corticosteroids, oral NSAIDs, and oral acetazolamide did not report significant differences between treatment groups. Therefore, large RCTs are needed to provide evidence-based recommendations for the optimum treatment of CME after cataract surgery.",

keywords = "Journal Article, Review",

author = "Wielders, {Laura H P} and Schouten, {Jan S A G} and Aberle, {Merel R} and Lambermont, {Verena A} and {van den Biggelaar}, {Frank J H M} and Bjorn Winkens and Simons, {Rob W P} and Nuijts, {Rudy M M A}",

year = "2017",

month = feb,

doi = "10.1016/j.jcrs.2016.06.041",

language = "English",

volume = "43",

pages = "276--284",

journal = "Journal of Cataract and Refractive Surgery",

issn = "0886-3350",

publisher = "Elsevier Science",

number = "2",

}

TY - JOUR

T1 - Treatment of cystoid macular edema after cataract surgery

AU - Wielders, Laura H P

AU - Schouten, Jan S A G

AU - Aberle, Merel R

AU - Lambermont, Verena A

AU - van den Biggelaar, Frank J H M

AU - Winkens, Bjorn

AU - Simons, Rob W P

AU - Nuijts, Rudy M M A

PY - 2017/2

Y1 - 2017/2

N2 - The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present. Ten RCTs were included in the systematic review. Five trials included at least 30 participants. Three RCTs showed a greater visual acuity improvement in patients treated with topical nonsteroidal antiinflammatory drugs (NSAIDs) than with a placebo. Other studies comparing the efficacy of topical NSAIDs, topical corticosteroids, sub-Tenon corticosteroids, oral NSAIDs, and oral acetazolamide did not report significant differences between treatment groups. Therefore, large RCTs are needed to provide evidence-based recommendations for the optimum treatment of CME after cataract surgery.

AB - The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present. Ten RCTs were included in the systematic review. Five trials included at least 30 participants. Three RCTs showed a greater visual acuity improvement in patients treated with topical nonsteroidal antiinflammatory drugs (NSAIDs) than with a placebo. Other studies comparing the efficacy of topical NSAIDs, topical corticosteroids, sub-Tenon corticosteroids, oral NSAIDs, and oral acetazolamide did not report significant differences between treatment groups. Therefore, large RCTs are needed to provide evidence-based recommendations for the optimum treatment of CME after cataract surgery.

KW - Journal Article

KW - Review

U2 - 10.1016/j.jcrs.2016.06.041

DO - 10.1016/j.jcrs.2016.06.041

M3 - (Systematic) Review article

C2 - 28366377

SN - 0886-3350

VL - 43

SP - 276

EP - 284

JO - Journal of Cataract and Refractive Surgery

JF - Journal of Cataract and Refractive Surgery

IS - 2

ER -