Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
| Original language | English |
|---|---|
| Pages (from-to) | 160-166 |
| Number of pages | 7 |
| Journal | European Neuropsychopharmacology |
| Volume | 41 |
| DOIs | |
| Publication status | Published - Dec 2020 |
Keywords
- Attention-deficit/hyperactivity disorder (ADHD)
- Transcriptomic assays
- Gene-expression signatures
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In: European Neuropsychopharmacology, Vol. 41, 12.2020, p. 160-166.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Transcriptome profiling in adult attention-deficit hyperactivity disorder
AU - Mortimer, Niall
AU - Sanchez-Mora, Cristina
AU - Rovira, Paula
AU - Vilar-Ribo, Laura
AU - Richarte, Vanesa
AU - Corrales, Montse
AU - Fadeuilhe, Christian
AU - Rivero, Olga
AU - Lesch, Klaus-Peter
AU - Casas, Miguel
AU - Antoni Ramos-Quiroga, Josep
AU - Soler Artigas, Maria
AU - Ribases, Marta
N1 - Funding Information: Over the course of this investigation, NM was supported by MiND Marie Sklodowska-Curie which received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 643051. P.R. is a recipient of a predoctoral fellowship from the Ag?ncia de Gesti? d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, Spain (2016FI_B 00899). C.S.M. was a recipient of a Sara Borrell contract from the Instituto de Salud Carlos III, Ministerio de Econom?a, Industria y Competitividad, Spain (CD15/00199). L.V. is a recipient of a pre-doctoral fellowship from the Instituto de Salud Carlos III, Spain (FI18/00285). MSA was a recipient of a contract from the Biomedical Network Research Center on Mental Health (CIBERSAM), Madrid, Spain and was also a recipient of a Juan de la Cierva Incorporacion contract from the Ministry of Science, Innovation and Universities, Spain (IJC2018-035346-I). M.R. is a recipient of a Miguel de Servet contract from the Instituto de Salud Carlos III, Spain (CP09/00119 and CPII15/00023). The research leading to these results has received funding from the European Union H2020 Programme (H2020/2014-2020) under grant agreements No. 667302 (CoCA) and No. 728018 (Eat2beNICE), from the Instituto de Salud Carlos III (PI16/01505, PI17/00289, PI18/01788, PI19/00721 and PI19/01224), and cofinanced by the European Regional Development Fund (ERDF), from the Pla estrat?gic de recerca i innovaci? en salut (PERIS); Generalitat de Catalunya (MENTAL-Cat; SLT006/17/287) and from the Ag?ncia de Gesti? d'Ajuts Universitaris i de Recerca-AGAUR, Generalitat de Catalunya (2017SGR1461). The work was also supported by the ECNP Network ?ADHD across the Lifespan? (https://www.ecnp.eu/research-innovation/ECNP-networks/List-ECNP-Networks/). We thank all the individuals who kindly participate in this study. Funding Information: Over the course of this investigation, NM was supported by MiND Marie Sklodowska-Curie which received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 643051 . P.R. is a recipient of a predoctoral fellowship from the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, Spain ( 2016FI_B 00899 ). C.S.M. was a recipient of a Sara Borrell contract from the Instituto de Salud Carlos III , Ministerio de Economía, Industria y Competitividad, Spain ( CD15/00199 ). L.V. is a recipient of a pre-doctoral fellowship from the Instituto de Salud Carlos III , Spain ( FI18/00285 ). MSA was a recipient of a contract from the Biomedical Network Research Center on Mental Health (CIBERSAM), Madrid, Spain and was also a recipient of a Juan de la Cierva Incorporacion contract from the Ministry of Science, Innovation and Universities, Spain (IJC2018-035346-I). M.R. is a recipient of a Miguel de Servet contract from the Instituto de Salud Carlos III, Spain ( CP09/00119 and CPII15/00023 ). The research leading to these results has received funding from the European Union H2020 Programme ( H2020/2014-2020 ) under grant agreements No. 667302 (CoCA) and No. 728018 (Eat2beNICE), from the Instituto de Salud Carlos III ( PI16/01505 , PI17/00289 , PI18/01788 , PI19/00721 and PI19/01224 ), and cofinanced by the European Regional Development Fund (ERDF), from the Pla estratègic de recerca i innovació en salut (PERIS); Generalitat de Catalunya (MENTAL-Cat; SLT006/17/287 ) and from the Agència de Gestió d'Ajuts Universitaris i de Recerca -AGAUR, Generalitat de Catalunya ( 2017SGR1461 ). The work was also supported by the ECNP Network ‘ADHD across the Lifespan’ (https://www.ecnp.eu/research-innovation/ECNP-networks/List-ECNP-Networks/). We thank all the individuals who kindly participate in this study. Publisher Copyright: © 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
AB - Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
KW - Attention-deficit/hyperactivity disorder (ADHD)
KW - Transcriptomic assays
KW - Gene-expression signatures
U2 - 10.1016/j.euroneuro.2020.11.005
DO - 10.1016/j.euroneuro.2020.11.005
M3 - Article
C2 - 33221139
SN - 0924-977X
VL - 41
SP - 160
EP - 166
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
ER -