Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias

Job A. J. Verdonschot; Mark R. Hazebroek; Kasper W. J. Derks; Arantxa Barandiaran Aizpurua; Jort J. Merken; Ping Wang; Joergen Bierau; Arthur van den Wijngaard; Simon M. Schalla; Myrurgia A. Abdul Hamid; Marc van Bilsen; Vanessa P. M. van Empel; Christian Knackstedt; Hans-Peter Brunner-La Rocca; Han G. Brunner; Ingrid P. C. Krapels; Stephane R. B. Heymans

doi:10.1093/eurheartj/ehx808

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias

Job A. J. Verdonschot, Mark R. Hazebroek, Kasper W. J. Derks, Arantxa Barandiaran Aizpurua, Jort J. Merken, Ping Wang, Joergen Bierau, Arthur van den Wijngaard, Simon M. Schalla, Myrurgia A. Abdul Hamid, Marc van Bilsen, Vanessa P. M. van Empel, Christian Knackstedt, Hans-Peter Brunner-La Rocca, Han G. Brunner, Ingrid P. C. Krapels, Stephane R. B. Heymans^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	864-873
Number of pages	10
Journal	European Heart Journal
Volume	39
Issue number	10
DOIs	https://doi.org/10.1093/eurheartj/ehx808
Publication status	Published - 7 Mar 2018

Keywords

Cardiomyopathy
Titin
Genetics
Prognosis
Genotype-phenotype
Mitochondrial
ESC WORKING GROUP
DILATED CARDIOMYOPATHY
PERICARDIAL DISEASES
POSITION STATEMENT
HEART-FAILURE
DIAGNOSIS
MUTATIONS
MORTALITY
RELEVANCE
VARIANTS

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10.1093/eurheartj/ehx808

Cite this

Verdonschot, J. A. J., Hazebroek, M. R., Derks, K. W. J., Aizpurua, A. B., Merken, J. J., Wang, P., Bierau, J., van den Wijngaard, A., Schalla, S. M., Hamid, M. A. A., van Bilsen, M., van Empel, V. P. M., Knackstedt, C., Brunner-La Rocca, H-P., Brunner, H. G., Krapels, I. P. C., & Heymans, S. R. B. (2018). Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. European Heart Journal, 39(10), 864-873. https://doi.org/10.1093/eurheartj/ehx808

Verdonschot, Job A. J. ; Hazebroek, Mark R. ; Derks, Kasper W. J. ; Aizpurua, Arantxa Barandiaran ; Merken, Jort J. ; Wang, Ping ; Bierau, Joergen ; van den Wijngaard, Arthur ; Schalla, Simon M. ; Hamid, Myrurgia A. Abdul ; van Bilsen, Marc ; van Empel, Vanessa P. M. ; Knackstedt, Christian ; Brunner-La Rocca, Hans-Peter ; Brunner, Han G. ; Krapels, Ingrid P. C. ; Heymans, Stephane R. B. / Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. In: European Heart Journal. 2018 ; Vol. 39, No. 10. pp. 864-873.

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title = "Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias",

keywords = "Cardiomyopathy, Titin, Genetics, Prognosis, Genotype-phenotype, Mitochondrial, ESC WORKING GROUP, DILATED CARDIOMYOPATHY, PERICARDIAL DISEASES, POSITION STATEMENT, HEART-FAILURE, DIAGNOSIS, MUTATIONS, MORTALITY, RELEVANCE, VARIANTS",

author = "Verdonschot, {Job A. J.} and Hazebroek, {Mark R.} and Derks, {Kasper W. J.} and Aizpurua, {Arantxa Barandiaran} and Merken, {Jort J.} and Ping Wang and Joergen Bierau and {van den Wijngaard}, Arthur and Schalla, {Simon M.} and Hamid, {Myrurgia A. Abdul} and {van Bilsen}, Marc and {van Empel}, {Vanessa P. M.} and Christian Knackstedt and {Brunner-La Rocca}, Hans-Peter and Brunner, {Han G.} and Krapels, {Ingrid P. C.} and Heymans, {Stephane R. B.}",

year = "2018",

month = mar,

day = "7",

doi = "10.1093/eurheartj/ehx808",

language = "English",

volume = "39",

pages = "864--873",

journal = "European Heart Journal",

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Verdonschot, JAJ, Hazebroek, MR , Derks, KWJ, Aizpurua, AB, Merken, JJ, Wang, P , Bierau, J, van den Wijngaard, A, Schalla, SM , Hamid, MAA , van Bilsen, M , van Empel, VPM , Knackstedt, C , Brunner-La Rocca, H-P , Brunner, HG , Krapels, IPC & Heymans, SRB 2018, 'Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias', European Heart Journal, vol. 39, no. 10, pp. 864-873. https://doi.org/10.1093/eurheartj/ehx808

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. / Verdonschot, Job A. J.; Hazebroek, Mark R.; Derks, Kasper W. J.; Aizpurua, Arantxa Barandiaran; Merken, Jort J.; Wang, Ping ; Bierau, Joergen; van den Wijngaard, Arthur; Schalla, Simon M.; Hamid, Myrurgia A. Abdul ; van Bilsen, Marc ; van Empel, Vanessa P. M.; Knackstedt, Christian ; Brunner-La Rocca, Hans-Peter ; Brunner, Han G.; Krapels, Ingrid P. C.; Heymans, Stephane R. B.

In: European Heart Journal, Vol. 39, No. 10, 07.03.2018, p. 864-873.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias

AU - Verdonschot, Job A. J.

AU - Hazebroek, Mark R.

AU - Derks, Kasper W. J.

AU - Aizpurua, Arantxa Barandiaran

AU - Merken, Jort J.

AU - Wang, Ping

AU - Bierau, Joergen

AU - van den Wijngaard, Arthur

AU - Schalla, Simon M.

AU - Hamid, Myrurgia A. Abdul

AU - van Bilsen, Marc

AU - van Empel, Vanessa P. M.

AU - Knackstedt, Christian

AU - Brunner-La Rocca, Hans-Peter

AU - Brunner, Han G.

AU - Krapels, Ingrid P. C.

AU - Heymans, Stephane R. B.

PY - 2018/3/7

Y1 - 2018/3/7

KW - Cardiomyopathy

KW - Titin

KW - Genetics

KW - Prognosis

KW - Genotype-phenotype

KW - Mitochondrial

KW - ESC WORKING GROUP

KW - DILATED CARDIOMYOPATHY

KW - PERICARDIAL DISEASES

KW - POSITION STATEMENT

KW - HEART-FAILURE

KW - DIAGNOSIS

KW - MUTATIONS

KW - MORTALITY

KW - RELEVANCE

KW - VARIANTS

U2 - 10.1093/eurheartj/ehx808

DO - 10.1093/eurheartj/ehx808

M3 - Article

C2 - 29377983

VL - 39

SP - 864

EP - 873

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 10

ER -