Tissue Engineering and Regenerative Medicine 2019: The Role of Biofabrication-A Year in Review

Tiago Ramos, Lorenzo Moroni*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Citations (Web of Science)
44 Downloads (Pure)

Abstract

Despite its relative youth, biofabrication is unceasingly expanding by assimilating the contributions from various disciplinary areas and their technological advances. Those developments have spawned the range of available options to produce structures with complex geometries while accurately manipulating and controlling cell behavior. As it evolves, biofabrication impacts other research fields, allowing the fabrication of tissue models of increased complexity that more closely resemble the dynamics of living tissue. The recent blooming and evolutions in biofabrication have opened new windows and perspectives that could aid the translational struggle in tissue engineering and regenerative medicine (TERM) applications. Based on similar methodologies applied in past years' reviews, we identified the most high-impact publications and reviewed the major concepts, findings, and research outcomes in the context of advancement beyond the state-of-the-art in the field. We first aim to clarify the confusion in terminology and concepts in biofabrication to therefore introduce the striking evolutions in three-dimensional and four-dimensional bioprinting of tissues. We conclude with a short discussion on the future outlooks for innovation that biofabrication could bring to TERM research.

Original languageEnglish
Pages (from-to)91-106
Number of pages16
JournalTissue Engineering. Part C. Methods
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • biofabrication
  • bioprinting
  • bioassembly
  • instructive scaffolds
  • BIOMIMETIC MICROFLUIDIC NETWORKS
  • 3D
  • CONSTRUCT
  • SCAFFOLD
  • TECHNOLOGY
  • HYDROGEL
  • DEVICES
  • TRENDS

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