Thermo-responsive magnetic Fe3O4@P(MEO(2)MAX-OEGMA(100-X)) NPs and their applications as drug delivery systems

Al Dine E Jamal, Z Ferjaoui, J Ghanbaja, T Roques-Carmes, A Meftah, T Hamieh, J Toufaily, R Schneider, S Marchal, E Gaffet, H Alem*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Web of Science)


The unique physical properties of the superparamagnetic nanoparticles (SPIONs) have made them candidates of choice in nanomedicine especially for diagnostic imaging, therapeutic applications and drug delivery based systems. In this study, superparamagnetic Fe3O4 NPs were synthesized and functionalized with a biocompatible thermoresponsive copolymer to obtain temperature responsive core/shell NPs. The ultimate goal of this work is to build a drug delivery system able to release anticancer drugs in the physiological temperatures range. The core/shell NPs were first synthesized and their chemical, physical, magnetic and thermo-responsive properties where fully characterized in a second step. The lower critical solution temperature (LCST) of the core/shell NPs was tuned in physiological media in order to release the cancer drug at a controlled temperature slightly above the body temperature to avoid any premature release of the drug. The core/shell NPs exhibiting the targeted LCST were then loaded with Doxurubicin (DOX) and the drug release properties were then studied with the temperature. Moreover the cytotoxicity tests have shown that the core/shell NPs had a very limited cytotoxicity up to concentration of 25 mu g/mL. This investigation showed that the significant release occurred at the targeted temperature in the physiological media making those nano-systems very promising for further use in drug delivery platform.

Original languageEnglish
Pages (from-to)738-747
Number of pages10
JournalInternational Journal of Pharmaceutics
Issue number2
Publication statusPublished - 5 Nov 2017
Externally publishedYes


  • Antineoplastic Agents chemistry
  • Cell Survival drug effects
  • Doxorubicin chemistry
  • Drug Liberation
  • HT29 Cells
  • Humans
  • Magnetite Nanoparticles chemistry
  • Polyethylene Glycols chemistry
  • Polymethacrylic Acids chemistry
  • Temperature
  • Antineoplastic Agents administration & dosage
  • Doxorubicin administration & dosage
  • Drug Delivery Systems
  • Magnetite Nanoparticles administration & dosage
  • Polyethylene Glycols administration & dosage
  • Polymethacrylic Acids administration & dosage

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