TY - JOUR
T1 - The Translational Genetics of Adhd and Related Phenotypes in Model Organisms
AU - Cabana-Domínguez, Judit
AU - Antón-Galindo, Ester
AU - Fernàndez-Castillo, Noèlia
AU - Singgih, Euginia L
AU - O'Leary, Aet
AU - Norton, William Hg
AU - Strekalova, Tatyana
AU - Schenck, Annette
AU - Reif, Andreas
AU - Lesch, Klaus-Peter
AU - Slattery, David
AU - Cormand, Bru
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2023/1
Y1 - 2023/1
N2 - Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder resulting from the interaction between genetic and environmental risk factors. It is well known that ADHD co-occurs frequently with other psychiatric disorders due, in part, to shared genetics factors. Although many studies have contributed to delineate the genetic landscape of psychiatric disorders, their specific molecular underpinnings are still not fully understood. The use of animal models can help us to understand the role of specific genes and environmental stimuli-induced epigenetic modifications in the pathogenesis of ADHD and its comorbidities. The aim of this review is to provide an overview on the functional work performed in rodents, zebrafish and fruit fly and highlight the generated insights into the biology of ADHD, with a special focus on genetics and epigenetics. We also describe the behavioral tests that are available to study ADHD-relevant phenotypes and comorbid traits in these models. Furthermore, we have searched for new models to study ADHD and its comorbidities, which can be useful to test potential pharmacological treatments.
AB - Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder resulting from the interaction between genetic and environmental risk factors. It is well known that ADHD co-occurs frequently with other psychiatric disorders due, in part, to shared genetics factors. Although many studies have contributed to delineate the genetic landscape of psychiatric disorders, their specific molecular underpinnings are still not fully understood. The use of animal models can help us to understand the role of specific genes and environmental stimuli-induced epigenetic modifications in the pathogenesis of ADHD and its comorbidities. The aim of this review is to provide an overview on the functional work performed in rodents, zebrafish and fruit fly and highlight the generated insights into the biology of ADHD, with a special focus on genetics and epigenetics. We also describe the behavioral tests that are available to study ADHD-relevant phenotypes and comorbid traits in these models. Furthermore, we have searched for new models to study ADHD and its comorbidities, which can be useful to test potential pharmacological treatments.
U2 - 10.1016/j.neubiorev.2022.104949
DO - 10.1016/j.neubiorev.2022.104949
M3 - (Systematic) Review article
C2 - 36368527
SN - 0149-7634
VL - 144
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 1
M1 - 104949
ER -