The Synergy of Electrospinning and Imprinting for Faithful Replication of Fiber Structures

Gozde Sahin, Erik Vrij, Rhiannon Grant*, Stefan Giselbrecht*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Electrospinning is a powerful method to fabricate structures resembling the fibrous texture of the native extracellular matrix. However, the random fiber deposition of the process hinders a faithful reproduction of the fiber mesh morphology on multiple samples, which raises difficulties in experimental designs to systematically test and assess cell response in vitro. A multi-replication process to precisely reproduce the fiber morphology on different cell culture substrates is developed. The process involves a decoupling of the fiber structure, material, and porosity by combining the key advantages of electrospinning and imprinting. With this, fiber patterns having a diameter between 0.4 and 2.8 µm are replicated on polycarbonate, polystyrene, poly(methyl methacrylate), and cyclic olefin copolymer films. Identical fiber morphology is, then, obtained on porous films having a pore diameter between 2 and 12 µm. Having full control over these parameters allows the multireplication process to engineer well-characterized cell microenvironments, which can potentially be used to further investigate complex cell–material interactions.

Original languageEnglish
Article number2300344
Number of pages12
JournalAdvanced Materials Technologies
Volume8
Issue number16
Early online date1 Jul 2023
DOIs
Publication statusPublished - 25 Aug 2023

Keywords

  • cell microenvironment
  • electrospinning
  • imprinting
  • nanotechnology
  • NANOIMPRINT LITHOGRAPHY
  • MICROFLUIDIC CELL
  • SOFT LITHOGRAPHY
  • SCAFFOLDS
  • INFILTRATION
  • POLYCAPROLACTONE
  • NANOFIBERS
  • POROSITY
  • MODEL

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