Abstract
Objective To investigate the relationship between obesity and sarcopenia in relation to overall survival (OS) and disease-specific survival (DSS) in high-grade endometrial cancer patients.Methods We conducted a retrospective study in women diagnosed with high-grade endometrial cancer (EC) between February 2006 and August 2017 in the Royal Cornwall Hospital who had abdominal computerized tomography (CT)-scan as part of routine staging work-up. Sarcopenia was assessed by measuring psoas-, paraspinal- and abdominal wall muscles on CT and defined by skeletal muscle index <= 41 cm(2)/m(2). Sarcopenic obesity was defined as sarcopenia combined with body mass index (BMI) >= 30 kg/m(2).Results A total of 176 patients with median age of 70 years and median BMI of 29.4 kg/m(2) were included in the study. The majority of patients (38%) had endometrioid type histology. Sarcopenia was not associated with OS (P = 0.951) or DSS (P = 0.545) However, in multivariate analysis, sarcopenic obesity was associated with reduced OS in endometrioid endometrial cancer (EEC) patients (P = 0.048).Conclusion Sarcopenic obesity is associated with OS in high-grade EEC patients, while sarcopenia without obesity is not related to OS or DSS in high-grade EC. In non-endometrioid endometrial cancer, there is no association between sarcopenic obesity and survival.
Original language | English |
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Pages (from-to) | 248-255 |
Number of pages | 8 |
Journal | International Journal of Gynecology & Obstetrics |
Volume | 154 |
Issue number | 2 |
Early online date | 26 Feb 2021 |
DOIs | |
Publication status | Published - Aug 2021 |
Keywords
- endometrial cancer
- obesity
- sarcopenia
- surgical complications
- survival
- WOMEN
- PARADOX
- BODY-MASS-INDEX
- OVERWEIGHT
- OUTCOMES
- SKELETAL-MUSCLE INDEX
- AGE