The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts

Paul M Putora; Dirk De Ruysscher; Markus Glatzer; Joachim Widder; Paul Van Houtte; Esther G C Troost; Ben J Slotman; Sara Ramella; Christoph Pöttgen; Stephanie Peeters; Ursula Nestle; Fiona McDonald; Cecile Le Pechoux; Rafal Dziadziuszko; José Belderbos; Corinne Faivre-Finn

doi:10.1016/j.radonc.2019.11.022

The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts

Paul M Putora^*, Dirk De Ruysscher, Markus Glatzer, Joachim Widder, Paul Van Houtte, Esther G C Troost, Ben J Slotman, Sara Ramella, Christoph Pöttgen, Stephanie Peeters, Ursula Nestle, Fiona McDonald, Cecile Le Pechoux, Rafal Dziadziuszko, José Belderbos, Corinne Faivre-Finn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Abstract

BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).

METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.

RESULTS: For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.

CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	145
Early online date	27 Dec 2019
DOIs	https://doi.org/10.1016/j.radonc.2019.11.022
Publication status	Published - Apr 2020

Keywords

Decision-making
Small cell lung cancer
Prophylactic cranial Irradiation
Postoperative thoracic radiotherapy
BODY RADIATION-THERAPY
EUROPEAN IASLC
STAGES-I
SURGERY
CHEMOTHERAPY
CARCINOMA
TRIAL

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10.1016/j.radonc.2019.11.022

Cite this

Putora, P. M., De Ruysscher, D., Glatzer, M., Widder, J., Van Houtte, P., Troost, E. G. C., Slotman, B. J., Ramella, S., Pöttgen, C., Peeters, S., Nestle, U., McDonald, F., Le Pechoux, C., Dziadziuszko, R., Belderbos, J., & Faivre-Finn, C. (2020). The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts. Radiotherapy and Oncology, 145, 45-48. https://doi.org/10.1016/j.radonc.2019.11.022

@article{79a221f0779d4960b2b4164c7e1d3b53,

title = "The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts",

abstract = "BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.RESULTS: For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.",

keywords = "Decision-making, Small cell lung cancer, Prophylactic cranial Irradiation, Postoperative thoracic radiotherapy, BODY RADIATION-THERAPY, EUROPEAN IASLC, STAGES-I, SURGERY, CHEMOTHERAPY, CARCINOMA, TRIAL",

author = "Putora, {Paul M} and {De Ruysscher}, Dirk and Markus Glatzer and Joachim Widder and {Van Houtte}, Paul and Troost, {Esther G C} and Slotman, {Ben J} and Sara Ramella and Christoph P{\"o}ttgen and Stephanie Peeters and Ursula Nestle and Fiona McDonald and {Le Pechoux}, Cecile and Rafal Dziadziuszko and Jos{\'e} Belderbos and Corinne Faivre-Finn",

year = "2020",

month = apr,

doi = "10.1016/j.radonc.2019.11.022",

language = "English",

volume = "145",

pages = "45--48",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

}

Putora, PM, De Ruysscher, D, Glatzer, M, Widder, J, Van Houtte, P, Troost, EGC, Slotman, BJ, Ramella, S, Pöttgen, C, Peeters, S, Nestle, U, McDonald, F, Le Pechoux, C, Dziadziuszko, R, Belderbos, J & Faivre-Finn, C 2020, 'The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts', Radiotherapy and Oncology, vol. 145, pp. 45-48. https://doi.org/10.1016/j.radonc.2019.11.022

TY - JOUR

T1 - The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer

T2 - Patient selection among ESTRO experts

AU - Putora, Paul M

AU - De Ruysscher, Dirk

AU - Glatzer, Markus

AU - Widder, Joachim

AU - Van Houtte, Paul

AU - Troost, Esther G C

AU - Slotman, Ben J

AU - Ramella, Sara

AU - Pöttgen, Christoph

AU - Peeters, Stephanie

AU - Nestle, Ursula

AU - McDonald, Fiona

AU - Le Pechoux, Cecile

AU - Dziadziuszko, Rafal

AU - Belderbos, José

AU - Faivre-Finn, Corinne

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.RESULTS: For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.

AB - BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.RESULTS: For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.

KW - Decision-making

KW - Small cell lung cancer

KW - Prophylactic cranial Irradiation

KW - Postoperative thoracic radiotherapy

KW - BODY RADIATION-THERAPY

KW - EUROPEAN IASLC

KW - STAGES-I

KW - SURGERY

KW - CHEMOTHERAPY

KW - CARCINOMA

KW - TRIAL

U2 - 10.1016/j.radonc.2019.11.022

DO - 10.1016/j.radonc.2019.11.022

M3 - Article

C2 - 31887577

VL - 145

SP - 45

EP - 48

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

ER -