The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer: Patient selection among ESTRO experts

Paul M Putora*, Dirk De Ruysscher, Markus Glatzer, Joachim Widder, Paul Van Houtte, Esther G C Troost, Ben J Slotman, Sara Ramella, Christoph Pöttgen, Stephanie Peeters, Ursula Nestle, Fiona McDonald, Cecile Le Pechoux, Rafal Dziadziuszko, José Belderbos, Corinne Faivre-Finn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).

METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and TRT for patients with resected SCLC. The treatment strategies were converted into decision trees and analyzed for consensus and discrepancies.

RESULTS: For patients with resected SCLC and positive lymph nodes most experts recommend prophylactic cranial irradiation and thoracic radiotherapy. For elderly patients with resected node negative SCLC, most experts do not recommend thoracic radiotherapy or prophylactic cranial irradiation.

CONCLUSION: PCI and TRT are considered in patients with resected SCLC and these treatments should be discussed with the patient in the context of shared decision-making.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalRadiotherapy and Oncology
Volume145
Early online date27 Dec 2019
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Decision-making
  • Small cell lung cancer
  • Prophylactic cranial Irradiation
  • Postoperative thoracic radiotherapy
  • BODY RADIATION-THERAPY
  • EUROPEAN IASLC
  • STAGES-I
  • SURGERY
  • CHEMOTHERAPY
  • CARCINOMA
  • TRIAL

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