The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study

Lucia Sideli; Monica Aas; Diego Quattrone; Daniele La Barbera; Caterina La Cascia; Laura Ferraro; Luis Alameda; Eva Velthorst; Giulia Trotta; Giada Tripoli; Adriano Schimmenti; Andrea Fontana; Charlotte Gayer-Anderson; Simona Stilo; Fabio Seminerio; Crocettarachele Sartorio; Giovanna Marrazzo; Antonio Lasalvia; Sarah Tosato; Ilaria Tarricone; Domenico Berardi; Giuseppe D'Andrea; Celso Arango; Manuel Arrojo; Miguel Bernardo; Julio Bobes; Julio Sanjuan; Jose Luis Santos; Paulo Rossi Menezes; Cristina Marta Del-Ben; Hannah E. Jongsma; Peter B. Jones; James B. Kirkbride; Pierre-Michel Llorca; Andrea Tortell; Baptiste Pignon; Lieuwe de Haan; Jean-Paul Selten; Jim Van Os; Bart P. Rutten; Richard Bentall; Marta Di Fort; Robin M. Murray; Craig Morgan; Helen L. Fisher; EU-GEI WP2 Group

doi:10.1007/s00127-023-02513-0

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study

Lucia Sideli^*, Monica Aas, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Luis Alameda, Eva Velthorst, Giulia Trotta, Giada Tripoli, Adriano Schimmenti, Andrea Fontana, Charlotte Gayer-Anderson, Simona Stilo, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria TarriconeDomenico Berardi, Giuseppe D'Andrea, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuan, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B. Jones, James B. Kirkbride, Pierre-Michel Llorca, Andrea Tortell, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P. Rutten, Richard Bentall, Marta Di Fort, Robin M. Murray, Craig Morgan, Helen L. Fisher, EU-GEI WP2 Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Original language	English
Pages (from-to)	1573-1580
Number of pages	8
Journal	Social Psychiatry and Psychiatric Epidemiology
Volume	58
Issue number	10
Early online date	1 Jun 2023
DOIs	https://doi.org/10.1007/s00127-023-02513-0
Publication status	Published - Oct 2023

Keywords

Childhood adversity
Cognition
Family history of psychosis
First episode
Polygenic risk score
Psychosis
FAMILIAL RISK
TRAUMA
SCHIZOPHRENIA
COGNITION
INTERPLAY
VALIDITY
MODERATE
OVERLAP
ABILITY
ONSET

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Cite this

Sideli, L., Aas, M., Quattrone, D., La Barbera, D., La Cascia, C., Ferraro, L., Alameda, L., Velthorst, E., Trotta, G., Tripoli, G., Schimmenti, A., Fontana, A., Gayer-Anderson, C., Stilo, S., Seminerio, F., Sartorio, C., Marrazzo, G., Lasalvia, A., Tosato, S., ... EU-GEI WP2 Group (2023). The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study. Social Psychiatry and Psychiatric Epidemiology, 58(10), 1573-1580. https://doi.org/10.1007/s00127-023-02513-0

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title = "The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study",

abstract = "This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.",

keywords = "Childhood adversity, Cognition, Family history of psychosis, First episode, Polygenic risk score, Psychosis, FAMILIAL RISK, TRAUMA, SCHIZOPHRENIA, COGNITION, INTERPLAY, VALIDITY, MODERATE, OVERLAP, ABILITY, ONSET",

author = "Lucia Sideli and Monica Aas and Diego Quattrone and {La Barbera}, Daniele and {La Cascia}, Caterina and Laura Ferraro and Luis Alameda and Eva Velthorst and Giulia Trotta and Giada Tripoli and Adriano Schimmenti and Andrea Fontana and Charlotte Gayer-Anderson and Simona Stilo and Fabio Seminerio and Crocettarachele Sartorio and Giovanna Marrazzo and Antonio Lasalvia and Sarah Tosato and Ilaria Tarricone and Domenico Berardi and Giuseppe D'Andrea and Celso Arango and Manuel Arrojo and Miguel Bernardo and Julio Bobes and Julio Sanjuan and Santos, {Jose Luis} and Menezes, {Paulo Rossi} and Del-Ben, {Cristina Marta} and Jongsma, {Hannah E.} and Jones, {Peter B.} and Kirkbride, {James B.} and Pierre-Michel Llorca and Andrea Tortell and Baptiste Pignon and {de Haan}, Lieuwe and Jean-Paul Selten and {Van Os}, Jim and Rutten, {Bart P.} and Richard Bentall and {Di Fort}, Marta and Murray, {Robin M.} and Craig Morgan and Fisher, {Helen L.} and {EU-GEI WP2 Group}",

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doi = "10.1007/s00127-023-02513-0",

language = "English",

volume = "58",

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journal = "Social Psychiatry and Psychiatric Epidemiology",

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Sideli, L, Aas, M, Quattrone, D, La Barbera, D, La Cascia, C, Ferraro, L, Alameda, L, Velthorst, E, Trotta, G, Tripoli, G, Schimmenti, A, Fontana, A, Gayer-Anderson, C, Stilo, S, Seminerio, F, Sartorio, C, Marrazzo, G, Lasalvia, A, Tosato, S, Tarricone, I, Berardi, D, D'Andrea, G, Arango, C, Arrojo, M, Bernardo, M, Bobes, J, Sanjuan, J, Santos, JL, Menezes, PR, Del-Ben, CM, Jongsma, HE, Jones, PB, Kirkbride, JB, Llorca, P-M, Tortell, A, Pignon, B, de Haan, L, Selten, J-P, Van Os, J, Rutten, BP, Bentall, R, Di Fort, M, Murray, RM, Morgan, C, Fisher, HL & EU-GEI WP2 Group 2023, 'The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study', Social Psychiatry and Psychiatric Epidemiology, vol. 58, no. 10, pp. 1573-1580. https://doi.org/10.1007/s00127-023-02513-0

TY - JOUR

T1 - The relationship between genetic liability, childhood maltreatment, and IQ

T2 - findings from the EU-GEI multicentric case-control study

AU - Sideli, Lucia

AU - Aas, Monica

AU - Quattrone, Diego

AU - La Barbera, Daniele

AU - La Cascia, Caterina

AU - Ferraro, Laura

AU - Alameda, Luis

AU - Velthorst, Eva

AU - Trotta, Giulia

AU - Tripoli, Giada

AU - Schimmenti, Adriano

AU - Fontana, Andrea

AU - Gayer-Anderson, Charlotte

AU - Stilo, Simona

AU - Seminerio, Fabio

AU - Sartorio, Crocettarachele

AU - Marrazzo, Giovanna

AU - Lasalvia, Antonio

AU - Tosato, Sarah

AU - Tarricone, Ilaria

AU - Berardi, Domenico

AU - D'Andrea, Giuseppe

AU - Arango, Celso

AU - Arrojo, Manuel

AU - Bernardo, Miguel

AU - Bobes, Julio

AU - Sanjuan, Julio

AU - Santos, Jose Luis

AU - Menezes, Paulo Rossi

AU - Del-Ben, Cristina Marta

AU - Jongsma, Hannah E.

AU - Jones, Peter B.

AU - Kirkbride, James B.

AU - Llorca, Pierre-Michel

AU - Tortell, Andrea

AU - Pignon, Baptiste

AU - de Haan, Lieuwe

AU - Selten, Jean-Paul

AU - Van Os, Jim

AU - Rutten, Bart P.

AU - Bentall, Richard

AU - Di Fort, Marta

AU - Murray, Robin M.

AU - Morgan, Craig

AU - Fisher, Helen L.

AU - EU-GEI WP2 Group

PY - 2023/10

Y1 - 2023/10

N2 - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

AB - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

KW - Childhood adversity

KW - Cognition

KW - Family history of psychosis

KW - First episode

KW - Polygenic risk score

KW - Psychosis

KW - FAMILIAL RISK

KW - TRAUMA

KW - SCHIZOPHRENIA

KW - COGNITION

KW - INTERPLAY

KW - VALIDITY

KW - MODERATE

KW - OVERLAP

KW - ABILITY

KW - ONSET

U2 - 10.1007/s00127-023-02513-0

DO - 10.1007/s00127-023-02513-0

M3 - Article

C2 - 37335320

SN - 0933-7954

VL - 58

SP - 1573

EP - 1580

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

IS - 10

ER -