Abstract
To investigate whether the numbers of lymph node metastases and coeliac ganglia delineated on [Ga-68]PSMA-HBED-CC PET/CT scans differ among datasets generated using different reconstruction algorithms.
Data were constructed using the BLOB-OS-TF, BLOB-OS and 3D-RAMLA algorithms. All reconstructions were assessed by two nuclear medicine physicians for the number of pelvic/paraaortal lymph node metastases as well the number of coeliac ganglia. Standardized uptake values (SUV) were also calculated in different regions.
At least one [Ga-68]PSMA-HBED-CC PET/CT-positive pelvic or paraaortal lymph node metastasis was found in 49 and 35 patients using the BLOB-OS-TF algorithm, in 42 and 33 patients using the BLOB-OS algorithm, and in 41 and 31 patients using the 3D-RAMLA algorithm, respectively, and a positive ganglion was found in 92, 59 and 24 of 100 patients using the three algorithms, respectively. Quantitatively, the SUVmean and SUVmax were significantly higher with the BLOB-OS algorithm than with either the BLOB-OS-TF or the 3D-RAMLA algorithm in all measured regions (p <0.001 for all comparisons). The differences between the SUVs with the BLOB-OS-TF- and 3D-RAMLA algorithms were not significant in the aorta (SUVmean, p = 0.93; SUVmax, p = 0.97) but were significant in all other regions (p <0.001 in all cases). The SUVmean ganglion/gluteus ratio was significantly higher with the BLOB-OS-TF algorithm than with either the BLOB-OS or the 3D-RAMLA algorithm and was significantly higher with the BLOB-OS than with the 3D-RAMLA algorithm (p <0.001 in all cases).
The results of [Ga-68]PSMA-HBED-CC PET/CT are affected by the reconstruction algorithm used. The highest number of lesions and physiological structures will be visualized using a modern algorithm employing time-of-flight information.
Original language | English |
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Pages (from-to) | 662-669 |
Number of pages | 8 |
Journal | European Journal of Nuclear Medicine and Molecular Imaging |
Volume | 44 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Prostate cancer
- PSMA PET/CT
- PSMA-HBED-CC
- Reconstruction algorithm
- Staging
- RECURRENT PROSTATE-CANCER
- GA-68-LABELED PSMA LIGAND
- TIME-OF-FLIGHT
- GA-68-PSMA PET/CT
- CARCINOMA
- DIAGNOSIS