The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

Brecht A. G. Willems, Cees Vermeer, Chris P. M. Reutelingsperger, Leon J. Schurgers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In the past few decades vitamin K has emerged from a single-function "haemostasis vitamin" to a "multi-function vitamin." The use of vitamin K antagonists (VKA) inevitably showed that the inhibition was not restricted to vitamin K dependent coagulation factors but also synthesis of functional extrahepatic vitamin K dependent proteins (VKDPs), thereby eliciting undesired side effects. Vascular calcification is one of the recently revealed detrimental effects of VKA. The discovery that VKDPs are involved in vascular calcification has propelled our mechanistic understanding of this process and has opened novel avenues for diagnosis and treatment. This review addresses mechanisms of VKDPs and their significance for physiological and pathological calcification.
Original languageEnglish
Pages (from-to)1620-1635
JournalMolecular Nutrition & Food Research
Issue number8
Publication statusPublished - Aug 2014


  • Gla-rich protein
  • Matrix Gla protein
  • Osteocalcin
  • Vascular calcification
  • Vitamin K

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