The (pro)renin receptor as a pharmacological target in cardiorenal diseaes

Heiko Funke-Kaiser; Thomas Unger

doi:10.1038/s41440-023-01424-6

The (pro)renin receptor as a pharmacological target in cardiorenal diseaes

Heiko Funke-Kaiser^*, Thomas Unger

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The (pro)renin receptor ((P)RR) is not only a member of the renin-angiotensin system (RAS) but also exerts several RAS-independent functions due to its multiple signal transductions pathways. In this mini-review, we shortly discuss the molecular functions of this receptor and its pathophysiological significance with a focus on cardiorenal diseases. Finally, we provide a short summary regarding a drug discovery and drug development program on small molecule-based renin/ prorenin receptor blockers (RERBs).

Original language	English
Pages (from-to)	2527-2534
Number of pages	8
Journal	Hypertension Research
Volume	46
Issue number	11
DOIs	https://doi.org/10.1038/s41440-023-01424-6
Publication status	Published - Nov 2023

Keywords

(Pro)renin receptor (P)RR
Cardiorenal
Cardiovascular
Drug target
End-organ damage
Oncology

Access to Document

10.1038/s41440-023-01424-6

Cite this

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title = "The (pro)renin receptor as a pharmacological target in cardiorenal diseaes",

abstract = "The (pro)renin receptor ((P)RR) is not only a member of the renin-angiotensin system (RAS) but also exerts several RAS-independent functions due to its multiple signal transductions pathways. In this mini-review, we shortly discuss the molecular functions of this receptor and its pathophysiological significance with a focus on cardiorenal diseases. Finally, we provide a short summary regarding a drug discovery and drug development program on small molecule-based renin/ prorenin receptor blockers (RERBs).",

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KW - (Pro)renin receptor (P)RR

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KW - Cardiovascular

KW - Drug target

KW - End-organ damage

KW - Oncology

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