The precision of pharmacokinetic parameters in dynamic contrast-enhanced magnetic resonance imaging: the effect of sampling frequency and duration

Hugo J. W. L. Aerts, K. Jaspers, Walter H. Backes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Web of Science)

Abstract

Dynamic contrast-enhanced magnetic resonance imaging is increasingly applied for tumour diagnosis and early evaluation of therapeutic responses over time. However, the reliability of pharmacokinetic parameters derived from DCE-MRI is highly dependent on the experimental settings. In this study, the effect of sampling frequency (f(s)) and duration on the precision of pharmacokinetic parameters was evaluated based on system identification theory and computer simulations. Both theoretical analysis and simulations showed that a higher value of the pharmacokinetic parameter K(trans) required an increasing sampling frequency. For instance, for similar results, a relatively low f(s) of 0.2 Hz was sufficient for a low K(trans) of 0.1 min(-1), compared to a high f(s) of 3 Hz for a high K(trans) of 0.5 min (1). For the parameter v(e), a decreasing value required a higher sampling frequency. A sampling frequency below 0.1 Hz systematically resulted in imprecise estimates for all parameters. For the K(trans) and v(e) parameters, the sampling duration should be above 2 min, but durations of more than 7 min do not further improve parameter estimates.
Original languageEnglish
Pages (from-to)5665-5678
JournalPhysics in Medicine and Biology
Volume56
Issue number17
DOIs
Publication statusPublished - 7 Sep 2011

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